17beta-estradiol downregulates interferon regulatory factor-1 in murine splenocytes.

17beta-estradiol downregulates interferon regulatory factor-1 in murine splenocytes. Research Abstract Details 

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17beta-estradiol downregulates interferon regulatory factor-1 in murine splenocytes. Abstract Text:

Andrea J Lengi,Rebecca A Phillips,Ebru Karpuzoglu,Sattar Ansar Ahmed,

Interferon regulatory factor-1 (IRF-1) is an important transcription factor that mediates interferon-gamma (IFN-gamma)-induced cell-signaling events. In this study, we examined whether 17beta-estradiol alters IRF-1 in splenic lymphocytes, in view of the immunomodulatory effects of this natural female sex hormone including its ability to alter IFN-gamma levels. We find that IRF-1 expression is markedly downregulated in splenocytes or purified T-cells from estrogen-treated mice at all time points studied when compared with their placebo counterparts. This decrease in IRF-1 in splenocytes from estrogen-treated mice is neither due to upregulation of IRF-1-interfering proteins (nucleophosmin or signal transducer and activator of transcription (STAT)-5) nor due to alternatively spliced IRF-1 mRNA. Given that IFN-gamma is a potent inducer of IRF-1, direct addition of recombinant IFN-gamma to splenocytes from either wild-type or IFN-gamma-knockout mice, or the addition of recombinant IFN-gamma to purified T-cells, was expected to stimulate IRF-1 expression. However, robust expression of IRF-1 in cells from estrogen-treated mice was not seen, unlike what was observed in cells from placebo-treated mice. Diminished IFN-gamma induction of IRF-1 in cells from estrogen-treated mice was noticed despite comparable phosphorylated STAT-1 activation. These studies are the first to show that estrogen regulates IFN-gamma-inducible IRF-1 in lymphoid cells, a finding that may have implications to IFN-gamma-regulated immune and vascular diseases.

17beta-estradiol downregulates interferon regulatory factor-1 in murine splenocytes. Publishing Authors By Initials

AJ Lengi,RA Phillips,E Karpuzoglu,SA Ahmed,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

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17beta-estradiol downregulates interferon regulatory factor-1 in murine splenocytes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of molecular endocrinology

VOLUME: 37

Page Numbers: 421-32

Journal Abbreviation: J. Mol. Endocrinol.

ISSN: 0952-5041

DAY: 3

MONTH: Dec

YEAR: 2006

17beta-estradiol downregulates interferon regulatory factor-1 in murine splenocytes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8902617

17beta-estradiol downregulates interferon regulatory factor-1 in murine splenocytes. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: genetics

Chemical & Substance for Abstract: 17beta-estradiol downregulates interferon regulatory factor-1 in murine splenocytes. Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for 17beta-estradiol downregulates interferon regulatory factor-1 in murine splenocytes.

AFFILIATION: Department of Biomedical Sciences and Pathology, Virginia-Maryland Regional College of Veterinary Medicine, 1410 Prices Fork Road, Blacksburg, VA 24061-0342, USA.

Country: England

AGENCY: United States NIAID

GRANT: 1R01 AI 051880-01A1

ACRONYM: AI

MEDLINETA: J Mol Endocrinol

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