13C-enrichment at carbons 8 and 2 of uric acid after 13C-labeled folate dose in man.

13C-enrichment at carbons 8 and 2 of uric acid after 13C-labeled folate dose in man. Research Abstract Details 

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13C-enrichment at carbons 8 and 2 of uric acid after 13C-labeled folate dose in man. Abstract Text:

Joseph E Baggott,Gregory S Gorman,Sarah L Morgan,Tsunenobu Tamura,

To evaluate folate-dependent carbon incorporation into the purine ring, we measured (13)C-enrichment independently at C(2) and C(8) of urinary uric acid (the final catabolite of purines) in a healthy male after an independent oral dose of [6RS]-5-[(13)C]-formyltetrahydrofolate ([6RS]-5-H(13)CO-H(4)folate) or 10-H(13)CO-7,8-dihydrofolate (10-H(13)CO-H(2)folate). The C(2) position was (13)C-enriched more than C(8) after [6RS]-5-H(13)CO-H(4)folate, and C(2) was exclusively enriched after 10-H(13)CO-H(2)folate. The enrichment of C(2) was greater from [6RS]-5-H(13)CO-H(4)folate than 10-H(13)CO-H(2)folate using equimolar bioactive doses. Our data suggest that formyl C of [6RS]-10-H(13)CO-H(4)folate was not equally utilized by glycinamide ribotide transformylase (enriches C(8)) and aminoimidazolecarboxamide ribotide (AICAR) transformylase (enriches C(2)), and the formyl C of 10-H(13)CO-H(2)folate was exclusively used by AICAR transformylase. 10-HCO-H(2)folate may function in vivo as the predominant substrate for AICAR transformylase in humans.

13C-enrichment at carbons 8 and 2 of uric acid after 13C-labeled folate dose in man. Publishing Authors By Initials

JE Baggott,GS Gorman,SL Morgan,T Tamura,

For similar heterocyclic compounds: alkaloids: xanthines: uric acid research abstracts see: heterocyclic compounds: alkaloids: xanthines: uric acid research

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13C-enrichment at carbons 8 and 2 of uric acid after 13C-labeled folate dose in man. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biochemical and biophysical research communication

VOLUME: 361

Page Numbers: 307-10

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 5

MONTH: 07

YEAR: 2007

13C-enrichment at carbons 8 and 2 of uric acid after 13C-labeled folate dose in man. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372516

13C-enrichment at carbons 8 and 2 of uric acid after 13C-labeled folate dose in man. Keywords Mesh Terms:

KEYWORDS: Uric Acid

MESH TERMS: urine

Chemical & Substance for Abstract: 13C-enrichment at carbons 8 and 2 of uric acid after 13C-labeled folate dose in man. Information

Substance Name: Uric Acid

Registry Number: 69-93-2

Grant and Affiliation Information for 13C-enrichment at carbons 8 and 2 of uric acid after 13C-labeled folate dose in man.

AFFILIATION: Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK064174

ACRONYM: DK

MEDLINETA: Biochem Biophys Res Commun

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