125I-iodinated benzazepines bind to melanin: implications for the noninvasive localization of pigmented melanomas.

125I-iodinated benzazepines bind to melanin: implications for the noninvasive localization of pigmented melanomas. Research Abstract Details 

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125I-iodinated benzazepines bind to melanin: implications for the noninvasive localization of pigmented melanomas. Abstract Text:

T Agui,G Bryant,J W Kebabian,S Larson,J M Saavedra,K Shigematsu,T Yamamoto,K Yokoyama,

Both the 5-R and the 5-S enantiomers of [125I]2,3,4,5-tetrahydro-8-iodo-3-methyl-5-phenyl-1H-3-benzazepin- 7-ol bind to melanin. The interaction between the 5-R enantiomer and melanin permits visualization of melanomas in mice with a noninvasive imaging procedure. Two lines of evidence suggest that the interaction between iodinated ligands and melanin is not related to the D-1 dopamine receptor, a known target for the 5-R enantiomer: first, melanin binds both enantiomers of the 125I-iodinated benzazepine while the D-1 receptor binds only the 5-R enantiomer; second, the melanin binding site displays only a 5-fold difference in affinity towards the R- and S-enantiomers of SCH 23390 while the D-1 receptor displays a 100-fold difference in affinity towards these two molecules. Because both enantiomers of the iodinated benzazepine bind to a human pigmented melanoma, we propose that such compounds may be of use in the diagnosis of pigmented melanoma: in addition, we discuss the possible application of these molecules as a supplement to existing technology for the localization of pigmented melanomas.

125I-iodinated benzazepines bind to melanin: implications for the noninvasive localization of pigmented melanomas. Publishing Authors By Initials

T Agui,G Bryant,JW Kebabian,S Larson,JM Saavedra,K Shigematsu,T Yamamoto,K Yokoyama,

For similar natural sciences: chemistry: chemistry, organic: isomerism: stereoisomerism research abstracts see: natural sciences: chemistry: chemistry, organic: isomerism: stereoisomerism research

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125I-iodinated benzazepines bind to melanin: implications for the noninvasive localization of pigmented melanomas. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of radiation applications an

VOLUME: 14

Page Numbers: 133-41

Journal Abbreviation:

ISSN: 0883-2897

DAY: 21

MONTH: 02

YEAR: 1987

125I-iodinated benzazepines bind to melanin: implications for the noninvasive localization of pigmented melanomas. Information

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LANGUAGE: eng

NlmUniqueID: 8611098

125I-iodinated benzazepines bind to melanin: implications for the noninvasive localization of pigmented melanomas. Keywords Mesh Terms:

KEYWORDS: Stereoisomerism

MESH TERMS: radionuclide imaging

Chemical & Substance for Abstract: 125I-iodinated benzazepines bind to melanin: implications for the noninvasive localization of pigmented melanomas. Information

Substance Name: (R)-2,3,4,5-Tetrahydro-8-chloro-3-methyl

Registry Number: 87075-17-0

Grant and Affiliation Information for 125I-iodinated benzazepines bind to melanin: implications for the noninvasive localization of pigmented melanomas.

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Country: UNITED STATES

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MEDLINETA: Int J Rad Appl Instrum B

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