1,2-hydroxypyridonates as contrast agents for magnetic resonance imaging: TREN-1,2-HOPO.

1,2-hydroxypyridonates as contrast agents for magnetic resonance imaging: TREN-1,2-HOPO. Research Abstract Details 

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1,2-hydroxypyridonates as contrast agents for magnetic resonance imaging: TREN-1,2-HOPO. Abstract Text:

Christoph J Jocher,Evan G Moore,Jide Xu,Stefano Avedano,Mauro Botta,Silvio Aime,Kenneth N Raymond,Christoph J Jocher,Evan G Moore,Jide Xu,Stefano Avedano,Mauro Botta,Silvio Aime,Kenneth N Raymond,

1,2-Hydroxypyridinones (1,2-HOPO) form very stable lanthanide complexes that may be useful as contrast agents for magnetic resonance imaging (MRI). X-ray diffraction of single crystals established that the solid-state structures of the Eu(III) and the previously reported [Inorg. Chem. 2004, 43, 5452] Gd(III) complex are identical. The recently discovered sensitizing properties of 1,2-HOPO chelates for Eu(III) luminescence [J. Am. Chem. Soc. 2006, 128, 10 067] allow for direct measurement of the number of water molecules coordinated to the metal center. Fluorescence measurements of the Eu(III) complex corroborate that, in solution, two water molecules coordinate the lanthanide (q = 2) as proposed from the analysis of NMRD profiles. In addition, fluorescence measurements have verified the anion binding interactions of lanthanide TREN-1,2-HOPO complexes in solution, studied by relaxivity, revealing only very weak oxalate binding (KA = 82.7 +/- 6.5 M-1). Solution thermodynamic studies of the metal complex and free ligand have been carried out using potentiometry, spectrophotometry, and fluorescence spectroscopy. The metal ion selectivity of TREN-1,2-HOPO supports the feasibility of using 1,2-HOPO ligands for selective lanthanide binding [pGd = 19.3 (2), pZn = 15.2 (2), pCa = 8.8 (3)].

1,2-hydroxypyridonates as contrast agents for magnetic resonance imaging: TREN-1,2-HOPO. Publishing Authors By Initials

CJ Jocher,EG Moore,J Xu,S Avedano,M Botta,S Aime,KN Raymond,CJ Jocher,EG Moore,J Xu,S Avedano,M Botta,S Aime,KN Raymond,

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1,2-hydroxypyridonates as contrast agents for magnetic resonance imaging: TREN-1,2-HOPO. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Inorganic chemistry

VOLUME: 46

Page Numbers: 9182-91

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ISSN: 0020-1669

DAY: 3

MONTH: 10

YEAR: 2007

1,2-hydroxypyridonates as contrast agents for magnetic resonance imaging: TREN-1,2-HOPO. Information

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LANGUAGE: eng

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Grant and Affiliation Information for 1,2-hydroxypyridonates as contrast agents for magnetic resonance imaging: TREN-1,2-HOPO.

AFFILIATION: Department of Chemistry, University of California, Berkeley, CA 94720-1460, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL 69832

ACRONYM: HL

MEDLINETA: Inorg Chem

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