1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) iodide, MTS-MPP+, a novel scanning cysteine accessibility method (SCAM) reagent for monoamine transporter studies.

1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) iodide, MTS-MPP+, a novel scanning cysteine accessibility method (SCAM) reagent for monoamine transporter studies. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) iodide, MTS-MPP+, a novel scanning cysteine accessibility method (SCAM) reagent for monoamine transporter studies. Abstract Text:

Alejandra Gallardo-Godoy,Melissa I Torres-Altoro,Kellie J White,Eric L Barker,David E Nichols,

A novel substituted cysteine accessibility method (SCAM) reagent was developed for monoamine uptake transporters. The new reagent, MTS-MPP(+), was a derivative of the neurotoxin and transporter substrate MPP(+). MTS-MPP(+) labeled cysteine residues introduced into the serotonin transporter protein. Although it did not prove to be a substrate, as is MPP(+), it appears to label cysteine residues lining the permeation pore of the transporter more readily than currently available nonspecific SCAM reagents.

1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) iodide, MTS-MPP+, a novel scanning cysteine accessibility method (SCAM) reagent for monoamine transporter studies. Publishing Authors By Initials

A Gallardo-Godoy,MI Torres-Altoro,KJ White,EL Barker,DE Nichols,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research

PUBMED ID PMID:

MEDLINE DATE:

1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) iodide, MTS-MPP+, a novel scanning cysteine accessibility method (SCAM) reagent for monoamine transporter studies. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Bioorganic & medicinal chemistry

VOLUME: 15

Page Numbers: 305-11

Journal Abbreviation: Bioorg. Med. Chem.

ISSN: 0968-0896

DAY: 29

MONTH: 09

YEAR: 2006

1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) iodide, MTS-MPP+, a novel scanning cysteine accessibility method (SCAM) reagent for monoamine transporter studies. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9413298

1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) iodide, MTS-MPP+, a novel scanning cysteine accessibility method (SCAM) reagent for monoamine transporter studies. Keywords Mesh Terms:

KEYWORDS: Structure-Activity Relationship

MESH TERMS: drug effects

Chemical & Substance for Abstract: 1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) iodide, MTS-MPP+, a novel scanning cysteine accessibility method (SCAM) reagent for monoamine transporter studies. Information

Substance Name: Cysteine

Registry Number: 52-90-4

Grant and Affiliation Information for 1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) iodide, MTS-MPP+, a novel scanning cysteine accessibility method (SCAM) reagent for monoamine transporter studies.

AFFILIATION: Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, IN 47906, USA.

Country: England

AGENCY: United States NIMH

GRANT: R01 MH060221-04

ACRONYM: MH

MEDLINETA: Bioorg Med Chem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

1-Methylpyridinium-4-4-phenylmethanethiosulfonate iodide, MTS-MPP+, a novel scanning cysteine accessibility method SCAM reagent for monoamine transporter studies Related Publications

• 1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) iodide, MTS-MPP+, a novel scanning cysteine accessibility method (SCAM) reagent for monoamine transporter studies.
• 327.
• Alpha1-adrenergic receptors mediate the locomotor response to systemic administration of (+/-)-3,4-methylenedioxymethamphetamine (MDMA) in rats.
• Bone mineral density loss and recovery during 48 months in first-time users of depot medroxyprogesterone acetate.
• C-terminal determinants of Kir4.2 channel expression.
• Changes in histamine and microbiological analyses in fresh and frozen tuna muscle during temperature abuse.
• Coassembly of flotillins induces formation of membrane microdomains, membrane curvature, and vesicle budding.
• Conventional energy and macronutrient variables distort the accuracy of children's dietary reports: illustrative data from a validation study of effect of order prompts.
• Effect of proteasome inhibition on toxicity and CYP3A23 induction in cultured rat hepatocytes: comparison with arsenite.
• Estimation efficiency and statistical power in arterial spin labeling fMRI.
• Expression of ATP-insensitive KATP channels in pancreatic beta-cells underlies a spectrum of diabetic phenotypes.
• Frequency of and factors associated with contact lens dissatisfaction and discontinuation.
• Head pitch affects muscle activity in the decerebrate cat hindlimb during walking.
• Hyperinsulinism in mice with heterozygous loss of K(ATP) channels.
• Identification of neuroprotective compounds of caenorhabditis elegans dopaminergic neurons against 6-OHDA.
• Impact of primary safety belt laws on alcohol-related front-seat occupant fatalities: five case studies.
• Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists.
• Patient suffering and caregiver compassion: new opportunities for research, practice, and policy.
• Polar and neutral lipid composition in the pelagic tunicate Pyrosoma atlanticum.
• Preventing youth violence and delinquency through a universal school-based prevention approach.
• Rank-order versus mean based statistics for neuroimaging.
• Reliability of grading lissamine green conjunctival staining.
• Spontaneous, intervesicular transfer rates of fluorescent, acyl chain-labeled phosphatidylcholine analogs.
• The Contact Lens and Tear Film Laboratory, the Ohio State University College of Optometry.
• The correlates of dyadic synchrony in high-risk, low-income toddler boys.
• The proton electrochemical gradient across the plasma membrane of yeast is necessary for phospholipid flip.
• The role of the cytoplasmic pore in inward rectification of Kir2.1 channels.
• Use of stable nitrogen isotopes and permeable membrane devices to study what factors influence freshwater mollusk survival in the Conasauaga River.
• Variation in probability of first reproduction of Weddell seals.
• WAY-100635 is a potent dopamine D4 receptor agonist.