-Arrestin-Dependent {micro}-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases (ERKs) Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation.

-Arrestin-Dependent {micro}-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases (ERKs) Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

-Arrestin-Dependent {micro}-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases (ERKs) Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation. Abstract Text:

Hui Zheng,Horace H Loh,Ping-Yee Law,Hui Zheng,Horace H Loh,Ping-Yee Law,Hui Zheng,Horace H Loh,Ping-Yee Law,Hui Zheng,Horace H Loh,Ping-Yee Law,

The cellular location of extracellular signal-regulated kinases (ERKs) activated by a G protein-coupled receptor was shown to be dependent on the pathway that mediated their activation. In general, fast activation of ERKs (2 min) mediated by G proteins resulted in the nuclear translocation of phosphorylated ERKs, whereas a slower activation of ERKs (10 min) mediated by beta-arrestins resulted in the cytosolic retention of the phosphorylated ERKs. However, we observed distinct differences from this established ERKs cellular itinerary with the mu-opioid receptor-activated ERKs. Agonists such as morphine and methadone activated ERKs via the protein kinase C-dependent pathway but not the beta-arrestin-dependent pathway. The activated ERKs did not translocate into the nucleus, but phosphorylated 90-kDa ribosomal S6 kinase and induced the activity of transcription factor cAMP response element-binding protein. In contrast, agonists such as etorphine and fentanyl activated ERKs in a beta-arrestin-dependent manner. The phosphorylated ERKs translocated into the nucleus, resulting in increases in Elk-1 activity and GRK2 and beta-arrestin2 transcriptions. Thus, the cellular location of phosphorylated ERKs and subsequent activities on gene transcriptions are dictated by the agonist used to activate the receptor and the subsequent signaling pathway involved.

-Arrestin-Dependent {micro}-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases (ERKs) Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation. Publishing Authors By Initials

H Zheng,HH Loh,PY Law,H Zheng,HH Loh,PY Law,H Zheng,HH Loh,PY Law,H Zheng,HH Loh,PY Law,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

-Arrestin-Dependent {micro}-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases (ERKs) Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular pharmacology

VOLUME: 73

Page Numbers: 178-90

Journal Abbreviation: Mol. Pharmacol.

ISSN: 1521-0111

DAY: 18

MONTH: 10

YEAR: 2007

-Arrestin-Dependent {micro}-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases (ERKs) Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 35623

-Arrestin-Dependent {micro}-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases (ERKs) Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: -Arrestin-Dependent {micro}-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases (ERKs) Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for -Arrestin-Dependent {micro}-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases (ERKs) Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation.

AFFILIATION: Department of Pharmacology, Medical School, University of Minnesota. 6-120 Jackson Hall, 321 Church Street S.E., Minneapolis, MN 55455-0217. zhen0091@umn.edu.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Mol Pharmacol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

-Arrestin-Dependent {micro}-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases ERKs Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation Related Publications

• -Arrestin-Dependent {micro}-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases (ERKs) Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation.
• A firm persuasion in our work. Occupational therapy: a journey driven by curiosity.
• Aedes aegypti ferritin heavy chain homologue: feeding of iron or blood influences message levels, lengths and subunit abundance.
• Agonist-dependent postsynaptic effects of opioids on miniature excitatory postsynaptic currents in cultured hippocampal neurons.
• An assessment of chemical pollution from the MSC Napoli.
• An attempt to demonstrate neutralizing antibodies to the mammary tumour milk agent in mice.
• Deep proteome profiling of sera from never-smoked lung cancer patients.
• Differentiating intracranial aspergillosis from a high grade glioma using MRI and MR spectroscopic imaging.
• Distinct effects of individual opioids on the morphology of spines depend upon the internalization of mu opioid receptors.
• Fluid transport across the isolated porcine ciliary epithelium.
• Gs15p is there a better way to determine private surgical fees in new zealand?
• Interview therapy of psychosomatic arthritis.
• Kinematic condition for multicomponent lattice Boltzmann simulation.
• Modelling the hepatitis C virus epidemic in Australia.
• Modelling the population-level impact of vaccination on the transmission of human papillomavirus type 16 in Australia.
• Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia.
• Nonparaxial propagation of a cylindrical beam with Lanczos reduction.
• Novel fatty acids from the royal jelly of honeybees (Apis mellifera, L.).
• Osteotomy of the spine in the treatment of severe dorsal kyphosis; four cases.
• Phosphorylation of the delta-opioid receptor regulates its beta-arrestins selectivity and subsequent receptor internalization and adenylyl cyclase desensitization.
• Propagation of nonparaxial beams with a modified Arnoldi method.
• Ring location in cyclopropane fatty acid esters by a mass spectrometric method.
• Self-reported psychological States and physiological responses to different types of motivational general imagery.
• Some notes on hyperphoria with illustrative case histories.
• The hygiene of the scalp and hair.
• The importance of size and growth in infancy: integrated findings from systematic reviews of scientific evidence and lay perspectives.
• The role of a clinical director in developing an innovative assertive community treatment team targeting ethno-racial minority patients.
• The toxicological impacts of oil and chemically dispersed oil: UV mediated phototoxicity and implications for environmental effects, statutory testing and response strategies.
• Use of chewing gum in reducing postoperative ileus after elective colorectal resection: a systematic review.
• Use of colonic stents in emergent malignant left colonic obstruction: a markov chain monte carlo decision analysis.