Temporal lobe dysfunction in medication-naïve boys with attention-deficit/hyperactivity disorder during attention allocation and its relation to response variability.

Temporal lobe dysfunction in medication-naïve boys with attention-deficit/hyperactivity disorder during attention allocation and its relation to response variability. Research Abstract Details 

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Temporal lobe dysfunction in medication-naïve boys with attention-deficit/hyperactivity disorder during attention allocation and its relation to response variability. Abstract Text:

Katya Rubia,Anna B Smith,Michael J Brammer,Eric Taylor,Katya Rubia,Anna B Smith,Michael J Brammer,Eric Taylor,

BACKGROUND: Patients with attention-deficit/hyperactivity disorder (ADHD) typically show fronto-striatal abnormalities during functions of cognitive control. In this study we investigate whether medication-naïve children with ADHD are impaired in temporo-parietal neural networks that mediate purely perceptual attention allocation to a behaviorally neutral oddball task. Furthermore, we explore the relationship between the neural substrates of attention allocation and response variability, typically increased in patients. METHOD: Event-related functional magnetic resonance imaging was used to compare brain activation of 17 medication-naïve boys with ADHD with that of 18 handedness- and IQ-matched healthy comparison boys during a visual oddball task that required the same response to oddball and standard trials. Furthermore, to explore the relationship between behavioral dispersion and attention networks, regression analyses were conducted between response variability and brain activation networks. RESULTS: Patients showed significantly reduced brain activation in left and right superior temporal lobes, basal ganglia, and posterior cingulate during the oddball versus standard contrast. The activation differences in superior temporal lobes correlated inversely with response variability in control subjects but not in patients with ADHD. CONCLUSIONS: Brain abnormalities in patients with ADHD are not confined to fronto-striatal networks mediating executive functions but are also observed in temporo-striatal and cingulate regions during perceptive visual attention processes. Furthermore, temporal lobe dysfunction in the context of perceptual attention might be related to their behavioral problems with response variability.

Temporal lobe dysfunction in medication-naïve boys with attention-deficit/hyperactivity disorder during attention allocation and its relation to response variability. Publishing Authors By Initials

K Rubia,AB Smith,MJ Brammer,E Taylor,K Rubia,AB Smith,MJ Brammer,E Taylor,

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Temporal lobe dysfunction in medication-naïve boys with attention-deficit/hyperactivity disorder during attention allocation and its relation to response variability. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biological psychiatry

VOLUME: 62

Page Numbers: 999-1006

Journal Abbreviation: Biol. Psychiatry

ISSN: 0006-3223

DAY: 21

MONTH: 06

YEAR: 2007

Temporal lobe dysfunction in medication-naïve boys with attention-deficit/hyperactivity disorder during attention allocation and its relation to response variability. Information

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LANGUAGE: eng

NlmUniqueID: 213264

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Grant and Affiliation Information for Temporal lobe dysfunction in medication-naïve boys with attention-deficit/hyperactivity disorder during attention allocation and its relation to response variability.

AFFILIATION: Department of Child Psychiatry, Institute of Psychiatry, King's College, London, United Kingdom. k.rubia@iop.kcl.ac.uk

Country: United States

AGENCY: United Kingdom Wellcome T

GRANT: 053272/z/98/z/jrs/jp

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MEDLINETA: Biol Psychiatry

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