The epsilon isoform of 14-3-3 protein is a component of the prion protein amyloid deposits of Gerstmann-Sträussler-Scheinker disease.

The epsilon isoform of 14-3-3 protein is a component of the prion protein amyloid deposits of Gerstmann-Sträussler-Scheinker disease. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The epsilon isoform of 14-3-3 protein is a component of the prion protein amyloid deposits of Gerstmann-Sträussler-Scheinker disease. Abstract Text:

Giuseppe Di Fede,Giorgio Giaccone,Lucia Limido,Michela Mangieri,Silvia Suardi,Gianfranco Puoti,Michela Morbin,Giulia Mazzoleni,Bernardino Ghetti,Fabrizio Tagliavini,

The 14-3-3 proteins are highly conserved, ubiquitous molecules involved in a variety of biologic events, such as transduction pathway modulation, cell cycle control, and apoptosis. Seven isoforms have been identified that are abundant in the brain, preferentially localized in neurons. Remarkable increases in 14-3-3 are seen in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease (CJD), and it has been found in pathologic inclusions of several neurodegenerative diseases. Moreover, the zeta isoform has been detected in prion protein (PrP) amyloid deposits of CJD patients. To further investigate the cerebral distribution of 14-3-3 in prion-related encephalopathies, we carried out an immunohistochemical and biochemical analysis of brain tissue from patients with Gerstmann-Sträussler-Scheinker disease (GSS) and sporadic, familial and acquired forms of CJD, using specific antibodies against the seven 14-3-3 isoforms. The study showed a strong immunoreactivity of PrP amyloid plaques of GSS patients for the 14-3-3 epsilon isoform, but not for the other isoforms. The epsilon isoform of 14-3-3 was not found in PrP deposits of CJD. These results indicate that the epsilon isoform of 14-3-3 is a component of PrP amyloid deposits of GSS and suggest that this is the sole 14-3-3 isoform specifically involved in the neuropathologic changes associated with this disorder.

The epsilon isoform of 14-3-3 protein is a component of the prion protein amyloid deposits of Gerstmann-Sträussler-Scheinker disease. Publishing Authors By Initials

G Di Fede,G Giaccone,L Limido,M Mangieri,S Suardi,G Puoti,M Morbin,G Mazzoleni,B Ghetti,F Tagliavini,

For similar nervous system: neurons: senile plaques research abstracts see: nervous system: neurons: senile plaques research

PUBMED ID PMID:

MEDLINE DATE:

The epsilon isoform of 14-3-3 protein is a component of the prion protein amyloid deposits of Gerstmann-Sträussler-Scheinker disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of neuropathology and experimental neurolo

VOLUME: 66

Page Numbers: 124-30

Journal Abbreviation: J. Neuropathol. Exp. Neurol.

ISSN: 0022-3069

DAY: 3

MONTH: Feb

YEAR: 2007

The epsilon isoform of 14-3-3 protein is a component of the prion protein amyloid deposits of Gerstmann-Sträussler-Scheinker disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985192

The epsilon isoform of 14-3-3 protein is a component of the prion protein amyloid deposits of Gerstmann-Sträussler-Scheinker disease. Keywords Mesh Terms:

KEYWORDS: Senile Plaques

MESH TERMS: pathology

Chemical & Substance for Abstract: The epsilon isoform of 14-3-3 protein is a component of the prion protein amyloid deposits of Gerstmann-Sträussler-Scheinker disease. Information

Substance Name: Prions

Registry Number: 0

Grant and Affiliation Information for The epsilon isoform of 14-3-3 protein is a component of the prion protein amyloid deposits of Gerstmann-Sträussler-Scheinker disease.

AFFILIATION: Department of Neuropathology and Neurology, Istituto Nazionale Neurologico Carlo Besta, Milan, Italy.

Country: United States

AGENCY: United States NIA

GRANT: AG010133

ACRONYM: AG

MEDLINETA: J Neuropathol Exp Neurol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The epsilon isoform of 14-3-3 protein is a component of the prion protein amyloid deposits of Gerstmann-Sträussler-Scheinker disease Related Publications

• A new function of microtubule-associated protein tau: involvement in chromosome stability.
• A novel phenotype of sporadic Creutzfeldt-Jakob disease.
• Acute toxicity of oxygenated and nonoxygenated imidazolium-based ionic liquids to Daphnia magna and Vibrio fischeri.
• Atypical tauopathy with massive involvement of the white matter.
• The epsilon isoform of 14-3-3 protein is a component of the prion protein amyloid deposits of Gerstmann-Sträussler-Scheinker disease.
• [Action of testosterone and vitamin E on senile skin.]
• [Case report of vegetating bromodermatitis]
• [Cytodiagnosis of oral manifestations in chronic bullous pemphigus vulgaris.]
• [Long-term results in the use of modern therapeutic methods in recent syphilis]
• [Rothmund-Thompson syndrome. Clinical contribution]