HIV DNA and dementia in treatment-naïve HIV-1-infected individuals in Bangkok, Thailand.

HIV DNA and dementia in treatment-naïve HIV-1-infected individuals in Bangkok, Thailand. Research Abstract Details 

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HIV DNA and dementia in treatment-naïve HIV-1-infected individuals in Bangkok, Thailand. Abstract Text:

Bruce Shiramizu,Silvia Ratto-Kim,Pasiri Sithinamsuwan,Samart Nidhinandana,Sataporn Thitivichianlert,George Watt,Mark deSouza,Thippawan Chuenchitra,Suchitra Sukwit,Suwicha Chitpatima,Kevin Robertson,Robert Paul,Cecilia Shikuma,Victor Valcour,

High HIV-1 DNA (HIV DNA) levels in peripheral blood mononuclear cells (PBMC) correlate with HIV-1-associated dementia (HAD) in patients on highly active antiretroviral therapy (HAART). If this relationship also exists among HAART-naïve patients, then HIV DNA may be implicated in the pathogenesis of HAD. In this study, we evaluated the relationship between HIV DNA and cognition in subjects naïve to HAART in a neuro AIDS cohort in Bangkok, Thailand. Subjects with and without HAD were recruited and matched for age, gender, education, and CD4 cell count. PBMC and cellular subsets were analyzed for HIV DNA using real-time PCR. The median log(10) HIV DNA copies per 10(6) PBMC for subjects with HAD (n=15) was 4.27, which was higher than that found in subjects without dementia (ND; n=15), 2.28, p<0.001. This finding was unchanged in a multivariate model adjusting for plasma HIV-1 RNA levels. From a small subset of individuals, in which adequate number of cells were available, more HIV DNA was in monocytes/macrophages from those with HAD compared to those with ND. These results are consistent with a previous report among HAART-experienced subjects, thus further implicating HIV DNA in the pathogenesis of HAD.

HIV DNA and dementia in treatment-naïve HIV-1-infected individuals in Bangkok, Thailand. Publishing Authors By Initials

B Shiramizu,S Ratto-Kim,P Sithinamsuwan,S Nidhinandana,S Thitivichianlert,G Watt,M deSouza,T Chuenchitra,S Sukwit,S Chitpatima,K Robertson,R Paul,C Shikuma,V Valcour,

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MEDLINE DATE:

HIV DNA and dementia in treatment-naïve HIV-1-infected individuals in Bangkok, Thailand. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: International journal of medical sciences

VOLUME: 4

Page Numbers: 13-8

Journal Abbreviation:

ISSN: 1449-1907

DAY: 6

MONTH: 12

YEAR: 2006

HIV DNA and dementia in treatment-naïve HIV-1-infected individuals in Bangkok, Thailand. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101213954

HIV DNA and dementia in treatment-naïve HIV-1-infected individuals in Bangkok, Thailand. Keywords Mesh Terms:

KEYWORDS: Receptors, IgG

MESH TERMS: analysis

Chemical & Substance for Abstract: HIV DNA and dementia in treatment-naïve HIV-1-infected individuals in Bangkok, Thailand. Information

Substance Name: Receptors, IgG

Registry Number: 0

Grant and Affiliation Information for HIV DNA and dementia in treatment-naïve HIV-1-infected individuals in Bangkok, Thailand.

AFFILIATION: Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI, USA. bshirami@hawaii.edu

Country: Unknown

AGENCY: United States NINDS

GRANT: U54NS43049

ACRONYM: NS

MEDLINETA: Int J Med Sci

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