Safety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax challenge in vaccinia-naïve and vaccinia-immune individuals.

Safety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax challenge in vaccinia-naïve and vaccinia-immune individuals. Research Abstract Details 

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Safety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax challenge in vaccinia-naïve and vaccinia-immune individuals. Abstract Text:

Janie Parrino,Lewis H McCurdy,Brenda D Larkin,Ingelise J Gordon,Steven E Rucker,Mary E Enama,Richard A Koup,Mario Roederer,Robert T Bailer,Zoe Moodie,Lin Gu,Lihan Yan,Barney S Graham, ,

Modified vaccinia Ankara (MVA) was evaluated as an alternative to Dryvax in vaccinia-naïve and vaccinia-immune adult volunteers. Subjects received intramuscular MVA or placebo followed by Dryvax challenge at 3 months. Two or more doses of MVA prior to Dryvax reduced severity of lesion formation, decreased magnitude and duration of viral shedding, and augmented post-Dryvax vaccinia-specific CD8(+) T cell responses and extracellular enveloped virus protein-specific antibody responses. MVA vaccination is safe and immunogenic and improves the safety and immunogenicity of subsequent Dryvax vaccination supporting the potential for using MVA as a vaccine in the general population to improve immunity to orthopoxviruses.

Safety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax challenge in vaccinia-naïve and vaccinia-immune individuals. Publishing Authors By Initials

J Parrino,LH McCurdy,BD Larkin,IJ Gordon,SE Rucker,ME Enama,RA Koup,M Roederer,RT Bailer,Z Moodie,L Gu,L Yan,BS Graham, ,

For similar viruses: dna viruses: poxviridae: chordopoxvirinae: orthopoxvirus: vaccinia virus research abstracts see: viruses: dna viruses: poxviridae: chordopoxvirinae: orthopoxvirus: vaccinia virus research

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Safety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax challenge in vaccinia-naïve and vaccinia-immune individuals. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: Vaccine

VOLUME: 25

Page Numbers: 1513-25

Journal Abbreviation: Vaccine

ISSN: 0264-410X

DAY: 7

MONTH: 11

YEAR: 2006

Safety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax challenge in vaccinia-naïve and vaccinia-immune individuals. Information

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LANGUAGE: eng

NlmUniqueID: 8406899

Safety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax challenge in vaccinia-naïve and vaccinia-immune individuals. Keywords Mesh Terms:

KEYWORDS: Vaccinia virus

MESH TERMS: immunology

Chemical & Substance for Abstract: Safety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax challenge in vaccinia-naïve and vaccinia-immune individuals. Information

Substance Name: Smallpox Vaccine

Registry Number: 0

Grant and Affiliation Information for Safety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax challenge in vaccinia-naïve and vaccinia-immune individuals.

AFFILIATION: Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Country: Netherlands

AGENCY: United States NIAID

GRANT: Z01 AI005062-03

ACRONYM: AI

MEDLINETA: Vaccine

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