Pituitary volume in treatment-naïve pediatric major depressive disorder.

Pituitary volume in treatment-naïve pediatric major depressive disorder. Research Abstract Details 

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Pituitary volume in treatment-naïve pediatric major depressive disorder. Abstract Text:

Frank P MacMaster,Aileen Russell,Yousha Mirza,Matcheri S Keshavan,S Preeya Taormina,Rashmi Bhandari,Courtney Boyd,Michelle Lynch,Michelle Rose,Jennifer Ivey,Gregory J Moore,David R Rosenberg,

BACKGROUND: Prior pilot investigation identified a larger pituitary gland volume (PGV) in pediatric patients with major depressive disorder (MDD) compared with healthy pediatric control subjects that was most prominent in boys with MDD. In this independent sample, we focus on gender differences in pituitary volume in a larger sample of pediatric patients with MDD. METHODS: Volumetric magnetic resonance imaging studies were conducted in 35 psychotropic drug-naïve children (15 boys, 20 girls), ages 8-17 years, and 35 case-matched healthy control subjects. RESULTS: The MDD boys had larger PGV (19%) compared with male control subjects. No significant diagnostic group differences in pituitary volume were observed in girls. Healthy boys had significantly smaller PGV (27%) than healthy girls, whereas MDD boys did not differ from girls with MDD. Nonfamilial (without a family history of mood disorder) boys with MDD had significantly larger PGV (35%) than male healthy control subjects and tended to have a larger PGV (27%) than familial (at least one first-degree relative with MDD) boys with MDD. Boys with familial MDD did not differ from control subjects. CONCLUSIONS: These findings provide new evidence of increased pituitary volume in psychotropic-naïve pediatric patients with MDD that seems to be more prominent in male patients with nonfamilial MDD.

Pituitary volume in treatment-naïve pediatric major depressive disorder. Publishing Authors By Initials

FP MacMaster,A Russell,Y Mirza,MS Keshavan,SP Taormina,R Bhandari,C Boyd,M Lynch,M Rose,J Ivey,GJ Moore,DR Rosenberg,

For similar reproductive and urinary physiology: reproduction: sex characteristics research abstracts see: reproductive and urinary physiology: reproduction: sex characteristics research

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Pituitary volume in treatment-naïve pediatric major depressive disorder. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biological psychiatry

VOLUME: 60

Page Numbers: 862-6

Journal Abbreviation: Biol. Psychiatry

ISSN: 0006-3223

DAY: 28

MONTH: 07

YEAR: 2006

Pituitary volume in treatment-naïve pediatric major depressive disorder. Information

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LANGUAGE: eng

NlmUniqueID: 213264

Pituitary volume in treatment-naïve pediatric major depressive disorder. Keywords Mesh Terms:

KEYWORDS: Sex Characteristics

MESH TERMS: pathology

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Grant and Affiliation Information for Pituitary volume in treatment-naïve pediatric major depressive disorder.

AFFILIATION: Department of Psychiatry and Behavioral Neurosciences, Wayne State University, and Children's Hospital of Michigan, Detroit, Michigan 48201, USA.

Country: United States

AGENCY: United States NIMH

GRANT: R01MH65122

ACRONYM: MH

MEDLINETA: Biol Psychiatry

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