(+)-Morphine and (-)-morphine stereoselectively attenuate the (-)-morphine-produced tail-flick inhibition via the naloxone-sensitive sigma receptor in the ventral periaqueductal gray of the rat.

(+)-Morphine and (-)-morphine stereoselectively attenuate the (-)-morphine-produced tail-flick inhibition via the naloxone-sensitive sigma receptor in the ventral periaqueductal gray of the rat. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

(+)-Morphine and (-)-morphine stereoselectively attenuate the (-)-morphine-produced tail-flick inhibition via the naloxone-sensitive sigma receptor in the ventral periaqueductal gray of the rat. Abstract Text:

Maia Terashvili,Hsiang-en Wu,Rachel M Moore,David R Harder,Leon F Tseng,

We have previously demonstrated that (+)-morphine and (-)-morphine pretreated spinally for 45 min stereoselectively attenuates the tail-flick inhibition produced by (-)-morphine given spinally in the mouse. The present study is then undertaken to determine if the same phenomenon observed in the mouse spinal cord can also take place in the ventral periaqueductal gray of the rat. Pretreatment with (+)-morphine for 45 min at 0.3 to 3.3 fmol dose-dependently attenuated the tail-flick inhibition produced by (-)-morphine (9 nmol) given into the ventral periaqueductal gray. Likewise, pretreatment with (-)-morphine for 45 min at a higher dose (3-900 pmol), which given alone did not affect the baseline tail-flick latency, also dose-dependently attenuated the tail-flick inhibition produced by (-)-morphine. Thus, (+)-morphine is approximately 270,000-fold more potent than (-)-morphine in attenuating the (-)-morphine-produced tail-flick inhibition. The attenuation of the (-)-morphine-produced tail-flick inhibition induced by (+)-morphine or (-)-morphine was dose-dependently reversed by (+)-naloxone (27.5 to 110 pmol) pretreatment for 50 min given into the ventral periaqueductal gray. Pretreatment with the sigma receptor antagonist BD1047 (N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide) (11-45 nmol) for 45 min given into the ventral periaqueductal gray also reversed dose-dependently the attenuation of the (-)-morphine-produced tail-flick inhibition induced by (+)-morphine or (-)-morphine, indicating that the effects are mediated by the activation of the sigma receptors. Since (+)-morphine, (-)-morphine and (+)-naloxone do not have any affinity for the naloxone-inaccessible sigma receptors, we therefore propose that (+)-morphine and (-)-morphine attenuate the (-)-morphine-produced tail-flick inhibition via the activation of the naloxone-sensitive sigma receptor originally proposed by Tsao and Su [Tsao, L.T., Su, T.P., 1997. Naloxone-sensitive, haloperidol-sensitive, [(3)H](+)-SKF-1047-binding protein partially purified from rat liver and rat brain membranes: an opioid/sigma receptor. Synapse 25, 117-124].

(+)-Morphine and (-)-morphine stereoselectively attenuate the (-)-morphine-produced tail-flick inhibition via the naloxone-sensitive sigma receptor in the ventral periaqueductal gray of the rat. Publishing Authors By Initials

M Terashvili,HE Wu,RM Moore,DR Harder,LF Tseng,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

PUBMED ID PMID:

MEDLINE DATE:

(+)-Morphine and (-)-morphine stereoselectively attenuate the (-)-morphine-produced tail-flick inhibition via the naloxone-sensitive sigma receptor in the ventral periaqueductal gray of the rat. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of pharmacology

VOLUME: 571

Page Numbers: 1-7

Journal Abbreviation: Eur. J. Pharmacol.

ISSN: 0014-2999

DAY: 5

MONTH: 06

YEAR: 2007

(+)-Morphine and (-)-morphine stereoselectively attenuate the (-)-morphine-produced tail-flick inhibition via the naloxone-sensitive sigma receptor in the ventral periaqueductal gray of the rat. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1254354

(+)-Morphine and (-)-morphine stereoselectively attenuate the (-)-morphine-produced tail-flick inhibition via the naloxone-sensitive sigma receptor in the ventral periaqueductal gray of the rat. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: physiopathology

Chemical & Substance for Abstract: (+)-Morphine and (-)-morphine stereoselectively attenuate the (-)-morphine-produced tail-flick inhibition via the naloxone-sensitive sigma receptor in the ventral periaqueductal gray of the rat. Information

Substance Name: Morphine

Registry Number: 57-27-2

Grant and Affiliation Information for (+)-Morphine and (-)-morphine stereoselectively attenuate the (-)-morphine-produced tail-flick inhibition via the naloxone-sensitive sigma receptor in the ventral periaqueductal gray of the rat.

AFFILIATION: Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Country: Netherlands

AGENCY: United States NIDA

GRANT: DA12588

ACRONYM: DA

MEDLINETA: Eur J Pharmacol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

+-Morphine and --morphine stereoselectively attenuate the --morphine-produced tail-flick inhibition via the naloxone-sensitive sigma receptor in the ventral periaqueductal gray of the rat Related Publications

• A microfluidic platform for sequential ligand labeling and cell binding analysis.
• A novel method of isolation, preservation, and expansion of human corneal endothelial cells.
• A novel phosphoinositide 3-kinase-dependent pathway for angiotensin II/AT-1 receptor-mediated induction of collagen synthesis in MES-13 mesangial cells.
• A novel signaling pathway for beta-adrenergic receptor-mediated activation of phosphoinositide 3-kinase in H9c2 cardiomyocytes.
• APETx1 from sea anemone Anthopleura elegantissima is a gating modifier peptide toxin of the human ether-a-go-go- related potassium channel.
• Acid corrosive injury in patients with a history of partial gastrectomy: outcome analysis.
• Advanced field-measurement method with three orthogonal Hall probes for an elliptically polarizing undulator.
• Arsenic methylation, urinary arsenic metabolites and human diseases: current perspective.
• Associations between the metabolic syndrome and its components, watching television and physical activity.
• Cell-type-specific regulation of RNA polymerase I transcription: a new frontier.
• Characterization of an LQT5-related mutation in KCNE1, Y81C: implications for a role of KCNE1 cytoplasmic domain in IKs channel function.
• Characterization of corneal pannus removed from patients with total limbal stem cell deficiency.
• Electrical remodeling in a canine model of ischemic cardiomyopathy.
• Evaluation of Forehand Receiving Quality in Junior- to Senior High School-Level Table Tennis Players: 1434: Board #197 May 30 9:30 AM - 11:00 AM.
• Functional mapping of rat barrel activation following whisker stimulation using activity-induced manganese-dependent contrast.
• Human amniotic epithelial cells as novel feeder layers for promoting ex vivo expansion of limbal epithelial progenitor cells.
• KCNE2 is colocalized with KCNQ1 and KCNE1 in cardiac myocytes and may function as a negative modulator of I(Ks) current amplitude in the heart.
• Long-term outcomes of amniotic membrane transplantation for repair of leaking glaucoma filtering blebs.
• Maturation-dependent microstructure length scale in the corpus callosum of fixed rat brains by magnetic resonance diffusion-diffraction.
• Niche regulation of corneal epithelial stem cells at the limbus.
• Paradoxical hyperalgesia induced by mu-opioid receptor agonist endomorphin-2, but not endomorphin-1, microinjected into the centromedial amygdala of the rat.
• Physical and chemical properties and adsorption type of activated carbon prepared from plum kernels by NaOH activation.
• QSAR analyses of skin penetration enhancers.
• Relationship Between Insulin Resistance And Body Composition in Highly TVained Swimmers: 1755: Board #43 May 31 9:00 AM 10:30 AM.
• Review. Pro- and anti-angiogenesis effects of resveratrol.
• The fate of limbal epithelial progenitor cells during explant culture on intact amniotic membrane.
• Unpacking immigration in youths' academic and occupational pathways.
• Upregulation of the creatine synthetic pathway in skeletal muscles of mature mdx mice.
• dextro-Morphine attenuates the morphine-produced conditioned place preference via the sigma(1) receptor activation in the rat.
• dextro-Naloxone or levo-naloxone reverses the attenuation of morphine antinociception induced by lipopolysaccharide in the mouse spinal cord via a non-opioid mechanism.