{delta}-Catenin-induced Dendritic Morphogenesis: AN ESSENTIAL ROLE OF p190RhoGEF INTERACTION THROUGH AKT1-MEDIATED PHOSPHORYLATION.

{delta}-Catenin-induced Dendritic Morphogenesis: AN ESSENTIAL ROLE OF p190RhoGEF INTERACTION THROUGH AKT1-MEDIATED PHOSPHORYLATION. Research Abstract Details 

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{delta}-Catenin-induced Dendritic Morphogenesis: AN ESSENTIAL ROLE OF p190RhoGEF INTERACTION THROUGH AKT1-MEDIATED PHOSPHORYLATION. Abstract Text:

Hangun Kim,Jeong-Ran Han,Jaejun Park,Minsoo Oh,Sarah E James,Sunghoe Chang,Qun Lu,Kwang Youl Lee,Hyunkyoung Ki,Woo-Joo Song,Kwonseop Kim,Hangun Kim,Jeong-Ran Han,Jaejun Park,Minsoo Oh,Sarah E James,Sunghoe Chang,Qun Lu,Kwang Youl Lee,Hyunkyoung Ki,Woo-Joo Song,Kwonseop Kim,

delta-Catenin was first identified through its interaction with Presenilin-1 and has been implicated in the regulation of dendrogenesis and cognitive function. However, the molecular mechanisms by which delta-catenin promotes dendritic morphogenesis were unclear. In this study, we demonstrated delta-catenin interaction with p190RhoGEF, and the importance of Akt1-mediated phosphorylation at Thr-454 residue of delta-catenin in this interaction. We have also found that delta-catenin overexpression decreased the binding between p190RhoGEF and RhoA, and significantly lowered the levels of GTP-RhoA but not those of GTP-Rac1 and -Cdc42. delta-Catenin T454A, a defective form in p190RhoGEF binding, did not decrease the binding between p190RhoGEF and RhoA. delta-Catenin T454A also did not lower GTP-RhoA levels and failed to induce dendrite-like process formation in NIH 3T3 fibroblasts. Furthermore, delta-catenin T454A significantly reduced the length and number of mature mushroom shaped spines in primary hippocampal neurons. These results highlight signaling events in the regulation of delta-catenin-induced dendrogenesis and spine morphogenesis.

{delta}-Catenin-induced Dendritic Morphogenesis: AN ESSENTIAL ROLE OF p190RhoGEF INTERACTION THROUGH AKT1-MEDIATED PHOSPHORYLATION. Publishing Authors By Initials

H Kim,JR Han,J Park,M Oh,SE James,S Chang,Q Lu,KY Lee,H Ki,WJ Song,K Kim,H Kim,JR Han,J Park,M Oh,SE James,S Chang,Q Lu,KY Lee,H Ki,WJ Song,K Kim,

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{delta}-Catenin-induced Dendritic Morphogenesis: AN ESSENTIAL ROLE OF p190RhoGEF INTERACTION THROUGH AKT1-MEDIATED PHOSPHORYLATION. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of biological chemistry

VOLUME: 283

Page Numbers: 977-87

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 8

MONTH: 11

YEAR: 2007

{delta}-Catenin-induced Dendritic Morphogenesis: AN ESSENTIAL ROLE OF p190RhoGEF INTERACTION THROUGH AKT1-MEDIATED PHOSPHORYLATION. Information

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LANGUAGE: eng

NlmUniqueID: 2985121

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AFFILIATION: College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Korea.

Country: United States

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MEDLINETA: J Biol Chem

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