The technique of patch clamp recording was invented by Bert Sakmann and Erwin Neher in 1981 for which they received the NOBEL prize. The technique is best suited for the study of the behaviour of single ion channels, or macroscopic currents in small cells or macro-patches. The whole cell technique allows one to control the composition of solutes on both sides of the membrane. - [Read Whole Cell Patch Clamp Technique]
This article briefly summarizes the use of this variant of the patch-clamp technique in isolated cardiac myocytes with an emphasis on practical suggestions. - [Read Whole-Cell Voltage Clamp of Isolated Heart Cells]