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Research is the process of going up alleys to see if they are blind. ~Marston Bates
dimer-homodimer-heterodimer
hi
i have some questions in generall.
how do you find out if an enzyme is a dimer, and if it is a homo- or heterodimer? perhaps it is a stupid...
Intramolecular lactame bridge (Asp-Lys)
Is that somebody who did a peptide with intramolecular lactame bridge.
What coupling reagent (HCTU, HATU) is more suitable for the cyclization...
Poor coupling
Hi guys!
I have a question concerning amino acid coupling. I find that the coupling of Fmoc-Arg(pbf)-OH very slow. I have tried several coupling...
HBr in acetic acid
Hi everybody!
we have purshased 33%HBr in acetic acid from two different suppliers. with one of them the time of debloking is 17 hours, with another...
Amide-group quantitation
Hi guys, does anyone here have the references on quantatitive measurement of free amide group during coupling step of SPPS? I have searched for the...
Methods for quantitatitive measurement of free amide group in coupling step o...
Hi guys, Does anyone here have any reference on the quantatitive measurement of free amide group during coupling step of SPPS? If yes, can you...
Chlorotoxin
Has aynyone here tried to synthesize chlorotoxin? Or any peptides with more than 3 disulfide bridgies? I'm about to start trying that. I've made my...
Heart Hormones eliminate Human Cancer
Yesterday, there was an alternative letter talking about healing cancer with heart hormones. I am wondering what peptides Dr. David Vesely, James A....
Poor reproducibility during peptide synthesis
I am now synthesizing a cyclic peptide (32 amino acide residues) contain a disulfide bond formed by SH of two Cys. My workmates have synthesized the...
Peptides containing tryptophan give pink powder
Dear collegues,
in our laboratory it occurs a problem: when one or more tryptophan are in a peptide sequence, during work up, after cleavage...
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Recently there has been an explosion of peptide utilization in all science fields, thus the growing demand for the synthesis of synthetic peptides. Peptide have been proved to act as great probes for the study of protein-protein interactions, the binding of ligands to the extracellular domains of cell surface proteins and receptors, studying epitopes in immunology or antibody-antigen interactions, the study of inhibitory peptides on protein functions such as inhibition of cancer-inducing proteins, and enzyme-protein substrate interactions to mention a few. Also the design and application of fluorescent substrate-based peptides can be used to determine the selectivity and activity of peptidases.
Synthetic peptides can be utilized as probes in all the previously mentioned scenarios as they all involve amino acid residue interactions . Although many of these protein interactions often involve amino acid residues from distant protein domains, there are many examples where short stretches of amino acids are vital for protein-protein interactions (acting as contiguous epitopes) and thus allow the application and the use of synthetic peptides for the study of a broad range of biological phenomena.
The creation of antibodies specific for a protein is quickly done using peptides. Peptides will not fold similarly to native proteins (due to their smaller size and lack of many native residues), however they can be useful in the generation of antibodies.
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