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Molecular Station is THE largest network of researchers, scientists and science lovers anywhere! Molekularna kolodvor je najveća mreža istraživača, znanstvenika i znanosti ljubitelje bilo gdje!
A science is any discipline in which the fool of this generation can go beyond the point reached by the genius of the last generation. A znanost je bilo koju disciplinu u kojoj je budalu od ove generacije može ići preko točku dostigla je genija od prošle generacije. ~Max Gluckman, Politics, Law and Ritual, 1965 ~ Max Gluckman, politika, zakona i Ritual, 1965
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Recently there has been an explosion of peptide utilization in all science fields, thus the growing demand for the synthesis of synthetic peptides. Peptide have been proved to act as great probes for the study of protein-protein interactions, the binding of ligands to the extracellular domains of cell surface proteins and receptors, studying epitopes in immunology or antibody-antigen interactions, the study of inhibitory peptides on protein functions such as inhibition of cancer-inducing proteins, and enzyme-protein substrate interactions to mention a few. Also the design and application of fluorescent substrate-based peptides can be used to determine the selectivity and activity of peptidases. U novije vrijeme došlo je do eksplozije peptida uporaba u svim poljima znanosti, tako raste i potražnja za sintezu sintetskih peptida. Peptida su dokazali da djeluje kao velika proba za studij protein-protein interakcije, obvezujući od liganada na extracellular domena stanične površine proteina i receptori, studiranje u epitopes imunologija ili antitijelo-antigen interakcije, proučavanje inhibitory protein peptida na funkcije kao što su inhibicija od raka-inducing proteina, i enzim-protein interakcije podloga spomenuti nekoliko. Također, dizajn i primjena fluorescencija podloga-based peptida može biti korišten za određivanje selektivnost i aktivnost peptidaza.
Synthetic peptides can be utilized as probes in all the previously mentioned scenarios as they all involve amino acid residue interactions . Synthetic peptida može biti korištena kao proba u svim prethodno spomenutih scenarija kao i svi oni uključuju aminokiselinska ostatka interakcije. Although many of these protein interactions often involve amino acid residues from distant protein domains, there are many examples where short stretches of amino acids are vital for protein-protein interactions (acting as contiguous epitopes) and thus allow the application and the use of synthetic peptides for the study of a broad range of biological phenomena. Iako su mnogi od tih protein interakcije često uključivati aminokiselina ostataka iz dalekih protein domene, postoji mnogo primjera gdje je kratko proteže od amino kiselina je vitalna za protein-protein interakcije (djeluje kao vanjski epitopes) i time omogućiti primjenu i upotrebu sintetskih peptida za proučavanje široki spektar bioloških fenomena.
The creation of antibodies specific for a protein is quickly done using peptides. Stvaranje protutijela specifična za protein je brzo učinio pomoću peptida. Peptides will not fold similarly to native proteins (due to their smaller size and lack of many native residues), however they can be useful in the generation of antibodies. Peptidi neće fold Slicno native proteina (zbog manje veličine i nedostatka mnogih ostataka native), međutim oni mogu biti korisni u generaciju protutijela.
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