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Immunology Home Immunology Home

At Molecular Station Immunology Home you will find information, protocols, bioinformatics, and links on: Na kolodvor molekularnu imunologiju Home ćete naći informacije, protokole, bioinformatika, i linkovi na:

Immunology Protocols Immunology Protocols

Immunology: Bioinformatics on Immunology Immunology: bioinformatiku na imunologiju

Immunology: Bioinformatics on Antigens Immunology: bioinformatiku na antigeni

ELISA ELISA

Latest Research in the Field of Immunology from the Journal Immunology, PubMed: Najnovija istraživanja u području imunologiju iz Časopis Immunology, PubMed:

Impact of MHC class I diversity on immune control of immunodeficiency virus r... Related Articles Utjecaj HLA razreda I raznolikosti na imuni kontrolu immunodeficiency virus r. .. Povezani članci

Impact of MHC class I diversity on immune control of immunodeficiency virus replication. Utjecaj HLA razreda I raznolikosti na imuni kontrolu immunodeficiency virus odgovor.

Nat Rev Immunol. NAT Rev Immunol. 2008 Jul 11; 2008 Srpanj 11;

Authors: Goulder PJ, Watkins DI Autorstvo: Goulder PJ, Watkins DI

The recent failure of the T-cell-based HIV vaccine trial led by Merck & Co., Inc. prompts the urgent need to refocus on the question of which T-cell responses are required to control HIV replication. Nedavnog kvara u T-cell-based HIV cjepivo suđenje na čelu s Merck & Co, Inc tome je hitna potreba da refocus na pitanje koje T-stanica odgovora su potrebni za kontrolu HIV odgovor. The well-described association between the expression of particular MHC class I molecules and successful containment of HIV or, in the macaque model, SIV replication provide a valuable starting point from which to evaluate more precisely what might constitute effective CD8(+) T-cell responses. Dobro opisano Povezanost između ekspresije pojedinih MHC molekule razreda I i uspješna containment of HIV ili, u macaque model, SIV odgovor pružaju vrijedne polazište iz kojeg se preciznije procijeniti što bi čine učinkovit CD8 (+) T-stanica reakcija. Here, we review recent studies of T-cell-mediated control of HIV and SIV infection, and offer insight for the design of a successful T-cell-based HIV vaccine in the future. Evo, mi pregled nedavne studije T-CELL-posredovan kontrolu HIV i SIV infekciju, i nude uvid za dizajn uspješna T-cell-based HIV cjepivo u budućnosti.

PMID: 18617886 [PubMed - as supplied by publisher] PMID: 18617886 [PubMed - kao dobivenim od izdavača]

WNT signalling in the immune system: WNT is spreading its wings. WNT signalizacija na imuni sustav: WNT je širenje svojih krila.

Nat Rev Immunol. NAT Rev Immunol. 2008 Jul 11; 2008 Srpanj 11;

Authors: Staal FJ, Luis TC, Tiemessen MM Autorstvo: Staal fj, Luis TC, Tiemessen MM

WNT proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. Proteina WNT su secreted morphogens koji je potreban za osnovne razvojne procese, kao što je stanica-sudbina specifikacija, praotac-stanična proliferacija i kontrolom nesimetrična stanična dioba, na mnogo različitih vrsta i organa. In blood and immune cells, WNT signalling controls the proliferation of progenitor cells and might also affect the cell-fate decisions of stem cells. U krvi i imunološke stanice, WNT signalizacija kontrole proliferacija praotac stanica i može također utjecati na cell-sudbina odluke kljun stanica. Recent studies indicate that WNT proteins also regulate effector T-cell development, regulatory T-cell activation and dendritic-cell maturation. Nedavne studije ukazuju da WNT proteini također regulirati djelovatelj razvoj limfocita, T-regulatornih stanica za aktivaciju i dendritične-stanica sazrijevanja. WNT signalling seems to function as a universal mechanism in leukocytes to establish a pool of undifferentiated cells for further selection, effector-cell maturation and terminal differentiation. WNT signalizacija izgleda da funkcioniraju kao univerzalnog mehanizma u leukociti uspostaviti bazen undifferentiated stanice za daljnja selekcija, djelovatelj-stanica sazrijevanja i terminalna diferencijacija. WNT signalling is therefore subject to strict molecular control, and dysregulated WNT signalling is implicated in the development of haematological malignancies. WNT signalizacija je, dakle, podložan strogim molecular kontrolu, i dysregulated WNT signalizacija je implicated u razvoju malignih haematological.

PMID: 18617885 [PubMed - as supplied by publisher] PMID: 18617885 [PubMed - kao dobivenim od izdavača]

New roles for TIM family members in immune regulation. Nova uloga za članove obitelji u TIM imuni regulacije.

Nat Rev Immunol. NAT Rev Immunol. 2008 Jul 11; 2008 Srpanj 11;

Authors: Kuchroo VK, Dardalhon V, Xiao S, Anderson AC Autorstvo: Kuchroo VK, Dardalhon V, Xiao J, Anderson AC

Members of the TIM (T-cell immunoglobulin domain and mucin domain) protein family are emerging as important regulators of immune responses. Članovi je TIM (T-stanica immunoglobulin domain i mucin domene) protein obitelji su u nastajanju kao važni regulatori za imuni odgovor. As their names imply, the TIM proteins were originally thought to be T-cell-specific molecules that served mainly to regulate T-helper-cell responses. Kao i njihova imena znače, TIM proteini su prvotno mislio da će T-CELL-specifičnih molekula koji su služili uglavnom za regulisanje T-helper cell-reakcija. However, the recent discovery that antigen-presenting cells also express TIM molecules and the identification of new TIM-protein ligands has expanded the known roles of the TIM proteins in immune regulation. No, nedavna otkrića da antigen-prezentiraju stanica i izraziti TIM molekula i identifikacija novih TIM-protein liganada je proširena poznate uloge u TIM proteina u regulaciji imunološke.

PMID: 18617884 [PubMed - as supplied by publisher] PMID: 18617884 [PubMed - kao dobivenim od izdavača]