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Signalling Biology Signalling is an integral part of the cell neural network. Phosphorylation and other protein modifications modulate this interaction. Post and discuss the study of protein-protein interactions, and signalling biology protocols and science here.


What happens to insulin once it has bound to its receptor?

What happens to insulin once it has bound to its receptor? - Signalling Biology

What happens to insulin once it has bound to its receptor? - Signalling is an integral part of the cell neural network. Phosphorylation and other protein modifications modulate this interaction. Post and discuss the study of protein-protein interactions, and signalling biology protocols and science here.


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Old 08-19-2014, 09:52 AM
Pipette Filler
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Question What happens to insulin once it has bound to its receptor?



Hi everyone,

I'm wondering what happens to insulin once it has bound its receptor. Is it internalized into the cell?

Thank you,
Annaa
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Old 09-04-2014, 01:44 PM
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Default Re: What happens to insulin once it has bound to its receptor?

In the isolated rat adipose cell, insulin induces a rapid and insulin concentration- and temperature-dependent translocation of its own receptor from the plasma membrane to an intracellular membrane fraction, and that this
translocation represents internalization of the insulin receptor through an endocytic like proces. Binding is reversible, saturable, and accompanied by internalization and degradation of the bound hormone in a temperature- and time-dependent manner.
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Old 09-09-2014, 01:26 PM
Pipette Filler
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Default Re: What happens to insulin once it has bound to its receptor?

Excellent answer, thank you!
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