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Signalling Biology Signalling is an integral part of the cell neural network. Phosphorylation and other protein modifications modulate this interaction. Post and discuss the study of protein-protein interactions, and signalling biology protocols and science here.


SHP1 and Phosphotyrosine in NK

SHP1 and Phosphotyrosine in NK - Signalling Biology

SHP1 and Phosphotyrosine in NK - Signalling is an integral part of the cell neural network. Phosphorylation and other protein modifications modulate this interaction. Post and discuss the study of protein-protein interactions, and signalling biology protocols and science here.


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Old 12-08-2008, 09:43 PM
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Default SHP1 and Phosphotyrosine in NK



What is the connection between SHP1 and phosphotyrosine or pY, in NK signaling pthway.
What is pY anyway?
thanks
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Old 02-17-2012, 05:54 AM
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Default Re: SHP1 and Phosphotyrosine in NK

A Toll-like receptor (TLR) bound to ligand recruits TIR-containing adaptor molecules leading to a signal cascade to activate NF-κB. After TNF receptor binding to FADD and TRADD, TRAF family members (TRAF2, 5, and 6), and the kinase RIP1. The TRAF/RIP complex recruits and activates TAK1, which induces activation of the IKK complex and downstream signaling via the NF-κB pathway. NF-κB plays an important role in chromatin remodeling. Unphosphorylated p65-containing NF-κB heterodimers or p50 homodimers bind to repressive histone deacetylases (HDACs) and suppress transcription. In the cytoplasm, p65 can be phosphorylated by IKK and protein kinase A (PKA), and in the nucleus by MSK1. Phosphorylation of histones by IKKα or MSK1 directly promote transcription.
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