Go Back   Science Forums Biology Forum Molecular Biology Forum Physics Chemistry Forum > General Forum > Science News and Views
Register Search Today's Posts Mark Forums Read

Science News and Views The latest news and publications from Nature, Science, Cell and other journals. Post science topics and your thoughts here. Anything science related goes here.


Skin Cancer: Stop Signal Identified

Skin Cancer: Stop Signal Identified - Science News and Views

Skin Cancer: Stop Signal Identified - The latest news and publications from Nature, Science, Cell and other journals. Post science topics and your thoughts here. Anything science related goes here.


Reply
 
LinkBack Thread Tools Display Modes
  #1  
Old 11-21-2011, 11:14 AM
obama's Avatar
Graduate Student
Points: 2,830, Level: 34 Points: 2,830, Level: 34 Points: 2,830, Level: 34
Activity: 0% Activity: 0% Activity: 0%
 
Join Date: Jan 2009
Location: Hannover Germany
Posts: 145
Thanks: 2
Thanked 25 Times in 21 Posts
Default Skin Cancer: Stop Signal Identified



An extraordinary breakthrough in understanding what stops a common form of skin cancer from developing could make new cancer treatments and prevention available to the public in five years.

In research published today in the leading international cancer journal, Cancer Cell, an international team of scientists led by Professor Stephen Jane and Dr Charbel Darido of Monash University's Department of Medicine at the Alfred Hospital, has discovered a gene that helps protect the body from squamous cell cancer (SCC) of the skin.

The Cancer Council estimates that two in three Australians will be diagnosed with skin cancer before the age of 70 with SCC being one of the most common forms. Up until now, its genetic basis has not been well understood, with surgical treatments the only option.

Professor Jane said the team discovered that a gene with an important role in skin development in the foetus is missing in adult SCC tumour cells. Although the researchers initially focused on skin cancer, they found that the protective gene is also lost in SCC that arises in other tissues, including head and neck cancers, that are often associated with a very poor outcome for the patient.

"Virtually every SCC tumour we looked at had almost undetectable levels of this particular gene, so its absence is a very profound driver of these cancers," Professor Jane said.

In collaboration with Associate Professor Rick Pearson from the Peter MacCallum Cancer Centre, the Monash researchers showed that loss of this particular gene knocks out the signal to stop skin cells from growing. Without this stop signal, the cells keep increasing in number and eventually forms a cancer.

Identifying this driver of cancer in skin and other organs provides a clear direction for developing strategies for both prevention and treatment in the relatively near future.

"Our research indicates that drugs already in clinical trials for other cancers may actually be effective in treating SCC - they just need to be applied to skin or head and neck cancers.

"This means that a number of the usual hurdles in getting therapies to trial have already been cleared, so patients could be reaping the benefits of this research in under five years," Professor Jane said.

"It's a similar case with prevention. There are strategies by which we could increase the expression of this gene that will likely afford some protection from skin cancer, for example in the form of a supplement in sun-cream. The molecules that would increase this expression, are very well validated, so there would be few barriers to applying them in clinical trials."

Source : Monash University
__________________
With Regards
Uday Kumar
[Only registered users see links. ]
Reply With Quote
Reply

Tags
cancer , cancer cell , cancer council , identified , signal , skin , skin cancer , stop , stop signal


Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are On

Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
Virus link identified in Skin cancer obama Science News and Views 0 10-03-2011 08:38 PM
Natural selection is proven wrong gim Biology Forum 3 05-15-2009 07:43 PM
Detection, markers and prognostic/predictive significance ofdisseminated tumor cells. scimedweb@mail.com Cell Biology and Cell Culture 0 04-10-2008 04:56 AM
Politics And Cannibalism? Introducing The Dourties, Chelsea, Bill, Hillary, Barrack Obama, George Bush, Jr., And All Of Capital Hill! jon_johnfrancisayres@yahoo.com Microbiology Forum 0 10-06-2007 05:59 AM


All times are GMT. The time now is 05:36 PM.


Powered by vBulletin® Version 3.8.4
Copyright ©2000 - 2014, Jelsoft Enterprises Ltd.
Copyright 2005 - 2012 Molecular Station | All Rights Reserved
Page generated in 0.14148 seconds with 16 queries