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Novel 'On-off Switch' Mechanism Stops Cancer In Its Tracks

Novel 'On-off Switch' Mechanism Stops Cancer In Its Tracks - Science News and Views

Novel 'On-off Switch' Mechanism Stops Cancer In Its Tracks - The latest news and publications from Nature, Science, Cell and other journals. Post science topics and your thoughts here. Anything science related goes here.


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Old 09-24-2009, 10:37 PM
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Default Novel 'On-off Switch' Mechanism Stops Cancer In Its Tracks



I read this news from Labslink.com today. It is really interesting.

A tiny bit of genetic material with no previously known function may hold the key to stopping the spread of cancer.

During early development, stem cells give rise to other cells that differentiate into all types of tissue. New cell division and proliferation stop as the organism matures. However, cancer can hijack this process and trigger the uncontrolled cell division that produces cancer tumors.

One mechanism that stops cell proliferation is a family of tumor-suppressor proteins (TSP) that bind to and block the function of proto-oncogenes, or genes that have the potential to trigger cancer.

Garenís team working with mice found that an RNA molecule from an area of the genome that does not produce proteins prevents a type of TSP from inactivating these incipient cancer genes. The TSP protein they studied, called PSF, is virtually identical in mice and humans, he said.

The Yale team succeeded in preventing the formation of tumors in mice by either increasing the amount of PSF or decreasing the amount of the non-coding RNA in a cell.

"The tumor cell stops proliferating and the tumor regresses in a mouse model of cancer, suggesting that both procedures could be the basis of a clinical protocol," said Garen, who is a member of Yale Cancer Center.

Garen and his colleagues plan to continue their studies on the mechanism that regulates the amount of PSF-binding RNA in a cell, which they believe is central to the origins of cancer.
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Old 10-05-2009, 05:27 PM
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Default Re: Novel 'On-off Switch' Mechanism Stops Cancer In Its Tracks

Wonderful. Thanks
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Old 11-08-2009, 01:49 AM
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Default Re: Novel 'On-off Switch' Mechanism Stops Cancer In Its Tracks

Valuable information.
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Old 05-24-2010, 03:08 AM
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Default Re: Novel 'On-off Switch' Mechanism Stops Cancer In Its Tracks

Very nice post. This will help possible client to get a quality person.
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Old 06-18-2010, 02:06 AM
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Default Re: Novel 'On-off Switch' Mechanism Stops Cancer In Its Tracks

Very nice post. This will help possible client to get a quality person.
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