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Single Transcription Factor can Reverse The Machinery

Single Transcription Factor can Reverse The Machinery - Science News and Views

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Old 02-06-2009, 07:23 PM
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Default Single Transcription Factor can Reverse The Machinery



Single Transcription Factor can Reverse The Machinery
In 2006 it was discovered that mature cells of the body can be converted back into embryonic stem cells called induced pluripotent stem cells (iPSC), The Research was first conduced on mice and then successfully worked for human cells. With expression of different combination of Transcription factors scientists came to conclusion that four transcription factors are required for this process. Oct-4, Sox-2, Klf-4 and c-myc. Later scientists tried to produce I PSC without c-myc and got success. Recently Researchers also worked on conversion of mature stem cells into embryonic stem cells and they concluded that this is possible only with two transcription factors, Klf-4 and Oct-4. But recently it is discovered that with only Oct-4 neuronal stem cells can be converted into iPSC. This research have implications for the use of reprogrammed stem cells for replacing cells lost to disease or injury.

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