orexin HIF-1 ATP free-radicals

[philstout]

what does this say about narcolepsy free radicals, ATP,
narcoleptics are in anaerobic respiration as far as mitochondria right ?

I have narcolepsy and understand that and orexin already


Hormone Links Sleep, Hunger And Metabolism
ScienceDaily (Nov. 15, 2007)
. . .
Orexin was already known for its role in sleep and hunger. Researchers, including Dr. Masashi Yanagisawa, professor of molecular genetics at UT Southwestern, had found that lack of orexin causes the sleep disorder narcolepsy.
. . .
This action of HIF-1 when stimulated by orexin is different than how it acts in tumors, Dr. Kodadek said. In tumors, HIF-1 changes cells' metabolism so they can burn sugar for energy without oxygen. This method is inefficient, but allows cells to stay alive.

Orexin, on the other hand, forces HIF-1 to switch cells to burn sugar using oxygen, which burns sugar faster but more efficiently. This strategy makes sense, they said, in terms of evolution.

[philstout]

I emailed the author of the study and asked if orexin was required for aerobic glycolysis or increases aerobic glycolysis (how would the heart survive?) and he responded he belived orexin increased aerobic glycolysis.