| | Re: Does the siRNA/dsRNA come from same gene as mRNA in RNA interference (RNAi)?
In many cases miRNAs are encoded on different genes; since a single miRNA may have hundreds of mRNA targets, the majority of miRNA-mRNA interactions are between RNAs encoded from different loci.
I recall running across a reference to an autoregulatory miRtron. This is an miRNA encoded in an intron of a gene; they are transcribed together, the intron is spliced out and the miRNA sequence is processed to a mature miRNA, which then suppresses translation of the mRNA with which it was transcribed. I don't recall the reference, I suppose I'm not ambitious enough to hunt.