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What is RNAi based loss of function screening?

What is RNAi based loss of function screening? - RNAi and SiRNA Forum

What is RNAi based loss of function screening? - Discuss and Post Questions in this forum about RNA interference and siRNA. RNAi and siRNA transfection, inhibition of endogenous genes, and miRNA and shRNA.


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Old 09-22-2011, 04:15 PM
Pipette Filler
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Default What is RNAi based loss of function screening?



I'm currently trying to understand a Nature article and can't find a definition for RNAi based loss of function screening that makes sense.

This is the context:
Cancer cells adapt their metabolic processes to drive macromolecular biosynthesis for rapid cell growth and proliferation. RNA interference (RNAi)-based loss-of-function screening has proven powerful for the identification of new and interesting cancer targets, and recent studies have used this technology in vivo to identify novel tumour suppressor genes
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