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-   -   What is RNAi based loss of function screening? (http://www.molecularstation.com/forum/rnai-sirna-forum/83621-what-rnai-based-loss-function-screening.html)

Katherine 09-22-2011 04:15 PM

What is RNAi based loss of function screening?
 
I'm currently trying to understand a Nature article and can't find a definition for RNAi based loss of function screening that makes sense.

This is the context:
Cancer cells adapt their metabolic processes to drive macromolecular biosynthesis for rapid cell growth and proliferation. RNA interference (RNAi)-based loss-of-function screening has proven powerful for the identification of new and interesting cancer targets, and recent studies have used this technology in vivo to identify novel tumour suppressor genes


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