| | |||||||
| Register | Search | Today's Posts | Mark Forums Read |
| RNAi and SiRNA Forum Discuss and Post Questions in this forum about RNA interference and siRNA. RNAi and siRNA transfection, inhibition of endogenous genes, and miRNA and shRNA. |
| | LinkBack | Thread Tools | Display Modes |
|
#1
| |||||||||||
| |||||||||||
| i know that andrew fire and craig mello discovered that dsRNA cause RNA interference but they could not deduce RNAi Pathway.( involving Dicer, RISC complex etc) 1) Can u please tell me who / which group/s deduced the RNAi pathway ( for bith si RNA and mi RNA)?? 2) or can u plese type link/ site for RNAi PATHWAY discovery (that includes scientists name and their experiments to deduce the pathway)??? 3) or can u type the site where i can freely download/ view the total and original paper/s of the scientists who discovered the pathway?? HELP PLEEEEEEASE!!!!!!!!!!!!!!!!!!!!!! thank u!! |
|
#2
| |||||||||||
| |||||||||||
| First recognized by Rich Jorgenson and his team in plants (Napoli et al., 1990******), the discovery of RNAi was the unexpected result of attempts to make the colour of petunia blooms more purple. An experiment was designed to overexpress the gene responsible for the production of anthocyanin pigments (chalcone synthetase (CHS)) through the introduction of a CHS transgene attached to a powerful promoter sequence. However, instead of increasing anthocyanin levels and therefore the deepness of bloom hue, the transgenic model showed apparent silencing of both the endogenous and exogenous CHS genes, and the flowers appeared variegated or white. |
| Tags |
| discovery , interference , mechanism , rna |
| Thread Tools | |
| Display Modes | |
|
|
| | ||||
| Thread | Thread Starter | Forum | Replies | Last Post |
| Human Cytome Project - Update 24 Jan. 2005 | Peter Van Osta | Cell Biology and Cell Culture | 1 | 08-01-2010 02:18 PM |
| RNA interference :: Discovery of mechanism??? PLEASE HELP!!!? | digdig | RNAi and SiRNA Forum | 1 | 09-21-2009 01:03 AM |
| Human Cytome Project - an idea - Update 19 April 2005 | Peter Van Osta | Cell Biology and Cell Culture | 1 | 06-01-2009 02:17 PM |
| Human Cytome Project - Update 6 Jan. 2005 | Peter Van Osta | Cell Biology and Cell Culture | 0 | 01-06-2005 10:18 AM |
| Druc discovery, diseases and the Human Cytome | Peter Van Osta | Cell Biology and Cell Culture | 0 | 09-24-2004 07:42 AM |