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-   -   miRNA Single or Double Stranded? (http://www.molecularstation.com/forum/rnai-sirna-forum/2873-mirna-single-double-stranded.html)

tonyz06 01-09-2008 02:43 PM

miRNA Single or Double Stranded?
 
Is MiRNA Single or Double Stranded?
I am having an argument with a co-worked :thumbs:

aftabac 01-09-2008 02:55 PM

Re: miRNA Single or Double Stranded?
 
well
miRNA are the miRNA That are manily involved in gene silencing by later making the siRNA, so they are double stranded in a way that both complementry stranded come over each other to make that double stranded.
any other suggestion.........


regards
aftab

Jon Moulton 01-22-2008 09:52 PM

Re: miRNA Single or Double Stranded?
 
Prior to associating with Argonaute, a free miRNA is a duplex. As the miRNA strand that will recognize target mRNAs is loaded onto miRISC, Argonaute cleaves the second strand which then dissociates from the complex. In its active form as part of miRISC, a miRNA is single-stranded.

You are both right, it is a matter of timing.


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