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-   -   Antisense oligonucleotides (ASOs) and ss-siRNA (http://www.molecularstation.com/forum/rna-techniques-forum/87265-antisense-oligonucleotides-asos-ss-sirna.html)

Alleunram 01-03-2013 01:00 AM

Antisense oligonucleotides (ASOs) and ss-siRNA
 
Hi everyone

Currently, single-stranded small interfering RNAs (ss-siRNAs) are used instead of double strand siRNA. In nucleotide sequence, the ss-siRNA is similar with antisense oligonucleotides (ASOs)??? Could you please explain what is difference between ASOs and ss-siRNAs?

Alle

Jon Moulton 01-08-2013 08:44 PM

Re: Antisense oligonucleotides (ASOs) and ss-siRNA
 
An siRNA oligo uses RISC for its activity. An antisense oligo either activates RNase-H activity or sterically blocks its target.


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