Go Back   Science Forums Biology Forum Molecular Biology Forum Physics Chemistry Forum > Molecular Research Topics Forum > RNA Techniques Forum
Register Search Today's Posts Mark Forums Read

RNA Techniques Forum Post and discuss RNA methods and RNA science related topics. RNA extraction, cDNA synthesis, RNA EMSA, and other RNA protocols.


Morpholinos for Duchenne muscular dystrophy: clinical trial

Morpholinos for Duchenne muscular dystrophy: clinical trial - RNA Techniques Forum

Morpholinos for Duchenne muscular dystrophy: clinical trial - Post and discuss RNA methods and RNA science related topics. RNA extraction, cDNA synthesis, RNA EMSA, and other RNA protocols.


Reply
 
LinkBack Thread Tools Display Modes
  #1  
Old 02-17-2009, 06:47 PM
Jon Moulton's Avatar
Post-Doc
Points: 8,875, Level: 65 Points: 8,875, Level: 65 Points: 8,875, Level: 65
Activity: 0% Activity: 0% Activity: 0%
 
Join Date: May 2007
Location: Corvallis, OR, USA
Posts: 256
Thanks: 3
Thanked 15 Times in 15 Posts
Default Morpholinos for Duchenne muscular dystrophy: clinical trial



AVI BioPharma has started a clinical trial of their AVI-4658 Morpholino oligo targeted to block splicing of exon 51 in the human Dystrophin transcript. This is an experimental therapeutic for some mutations causing Duchenne muscular dystrophy, designed to restore the reading frame and ameliorate the effects of a frame-shifting mutation. This is a systemic study involving intravenous injection of an unmodified Morpholino (note: Morpholinos are also called PMO, an acronym for phosphorodiamidate Morpholino oligomer).

[Only registered users see links. ]
ClinicalTrials.gov identifier: NCT00844597

Update 19 Feb 09: First patient dosed.
[Only registered users see links. ]
__________________
Jon D. Moulton, Ph.D.
Gene Tools, LLC
[Only registered users see links. ]

Last edited by Jon Moulton; 02-19-2009 at 03:51 PM. Reason: update
Reply With Quote
Reply

Tags
clinical , dmd , duchenne , dystrophy , morpholino , morpholinos , muscular , trial


Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are On

Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
Human Cytome Project - Update 24 Jan. 2005 Peter Van Osta Cell Biology and Cell Culture 1 08-01-2010 02:18 PM
Myotonic dystrophy and Morpholinos Jon Moulton Article Discussion 1 05-11-2010 05:24 AM
The latest thoughts on Clinical Proteomics J Halverson Protocols and Methods Forum 3 02-10-2010 11:45 PM
2nd Annual Neurodegenerative Disorders 2005 Ben Radford Protocols and Methods Forum 0 01-19-2005 02:10 PM
Human Cytome Project - Update 6 Jan. 2005 Peter Van Osta Cell Biology and Cell Culture 0 01-06-2005 11:18 AM


All times are GMT. The time now is 07:48 AM.


Powered by vBulletin® Version 3.8.4
Copyright ©2000 - 2014, Jelsoft Enterprises Ltd.
Copyright 2005 - 2012 Molecular Station | All Rights Reserved
Page generated in 0.14994 seconds with 16 queries