Originally Posted by amberpdidit
well, someone can correct me if I'm wrong but I believe that you can only multiplex with probe based chemistries.
This is not quite true. A lot of papers already proved that if two or more PCR products have enough differencies in there Tm (say >3C) it is no problem at all to multiplex the primer pairs with SYBR detection and melting-curve analysis. Recently I read a paper where 8 different tetracycline genes (namely tetA,B,C...) were effectively detected in a octaplex SYBR green real-time PCR. Besides there are already many instruments capable of doing high-resolution melting-curve (HRM) down to < 0.1C which further facilitate the multiplexing/detection.
So google a little and you'll find out