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MMTV as a reponsive element is a lucifierase reporter construct

MMTV as a reponsive element is a lucifierase reporter construct - Protocols and Methods Forum

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Old 05-12-2009, 11:35 AM
Scott Brown
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Default MMTV as a reponsive element is a lucifierase reporter construct




Hi,

I am aware of MMTV being a responsive element to glucocorticoids and androgens when in a lucifierase reporter construct. Does anyone know if MMTV is responsive to progesterone and oestrogen?

Regards

Scott

Scott Brown
PhD Candidate
Molecular Carcinogenesis Program
Children's Cancer Institute of Australia for Medical Research
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Old 05-13-2009, 01:53 AM
Aawara Chowdhury
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Default MMTV as a reponsive element is a lucifierase reporter construct

In <[Only registered users see links. ].net> ,
Scott Brown <[Only registered users see links. ].edu.au> wrote:



The MMTV LTR is responsive to glucocorticoids, some androgens (eg.
dihydrotestosterone), and progesterone. It is not responsive to
estrogens. This lack of responsiveness is very significant for
the biology of mouse mammary tumor virus (MMTV). I would check
papers by Stan McKnight from the mid to late 80's.

AC

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