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Trainings/Projects on Bioinformatics,Molecular Biology,MicroBiology,DrugDesigning and SAS Programming at Global Institute of Biotechnology

Trainings/Projects on Bioinformatics,Molecular Biology,MicroBiology,DrugDesigning and SAS Programming at Global Institute of Biotechnology - Protocols and Methods Forum

Trainings/Projects on Bioinformatics,Molecular Biology,MicroBiology,DrugDesigning and SAS Programming at Global Institute of Biotechnology - Post Any Protocol, Method, Technique, Procedure or Tips / Troubleshooting for any Molecular Biology Technique.


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Old 11-28-2007, 12:31 PM
Global Institute of Biotechnology
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Default Trainings/Projects on Bioinformatics,Molecular Biology,MicroBiology,DrugDesigning and SAS Programming at Global Institute of Biotechnology



GLOBAL INSTITUTE OF BIOTECHNOLOGY
( A unit of SVS Education Society, Regn No 1640 of 2005, Govt.A.P.)
3-6-276/2, Sai Triveni Chambers, Above Mahesh Bank, Hyderabad, A.P.

ABOUT OURSELVES

Global Institute of Biotechnology in its short span of existence for a
period of Three years has emerged as a premier Institute in the field
of Training and Research in Bioinformatics,Biotechnology and Other
Life Sciences.The Institute is equipped with the state of the art
laboratories in the above fields and is manned by suitably qualified
and experienced faculty.

In order to prepare the students to meet the needs of modern
Biotech,Pharma,and other Life Science Industries, the Institute is
also providing training and project work in SAS ( Statistics Analysis
Systems ) which has become a gold standard for analysis and management
of data in Clinical and Biological Research.

Similarly students of the Biotechnology course, wherein the emphasis
is on the wet lab experimentation, have been undergoing internship in
various biotech companies

The Institute proudly invites applications for Short/Long Term
Training Programmes and Research Projects as detailed below:

BIOINFORMATICS

During the past many years, the Genome of several organisms' including
manhave been completely or Partially sequenced. However these billions
of DNA bases do not tell us much about, what all these genes do what
is their exact role in the process of Development, growth, ageing and
disease. We know that ultimately proteins are coded by genes and
control life Processes. However elucidations of the functions of
proteins are not yet clear. This is where functional genomics,
proteomics and Bioinformatics is an amalgamation of the data in
biological sciences and tools of computing in information technology.
Bioinformatics uses computational power to catalogue, organize and
structure these complex databases and pieces them into meaningful
biological entities, to provide easy access to data on many
developments in the fields of Medical, Pharmaceutical, Agricultural,
Animal and Microbial Biotechnologies.

Computational tools have become increasingly important in processes
leading to new inventions in Biotechnology. Computer Aided Drug Design
(CADD) is a central part of the rational approach for Drug Discovery.
CADD is an inter disciplinary field, which includes computational
inputs from Chemistry, Biology, Pharmacology, Biotechnology,
Information Technology. Etc. This is an emerging field, with wide
range of applications. Various aspects of this field include Quantum
Chemistry, Molecular Mechanics, Molecular Docking, Quantitative
Structure Activity Relationship (3D QSAR), Conformational Analysis,
etc. A major component of CADD is Molecular Modeling and Screening of
the Substrate ligand interactions in silico.

Our endeavour is to crate a lively environment for the advancement of
Bioinformatics and to generate an innovative workforce in this
exciting and expanding field.

COURSE CONTENTS

Module:1 BIOLOGICAL DATABASES AND SEQUENCE ANALYSIS
(Duration: 1 month)

BIOLOGICAL DATABASES

* Introduction to Bioinformatics
* Molecular Databases
* Primary Databanks, GENEBANK, EMBL, DDBJ
* Secondary Databases, SWISSPORT, PIR, TrEMBL
* PFAM. INTERPRO
* Motif Database, PROSITE
* Structural Database (PDB)
* Classification Database(SCOP, CATH)
* Eukaryotic Promoter Database

.. SEQUENCE ANALYSIS

* Database similarity search
* Pair wise alignment
* Dot Matrix Comparison
* Needleman-Wunsch Algarithm
* Smith Waterman Algarithm
* Local Sequence Alignment
* Global Sequence Alignment
* Multiple Sequence Alignment
* Pattern, Motifs and Profiles
* Primer Designing

Module:2 GENOMICS AND PROTEOMICS

( Duration: 1 Month )

GENOMICS

* Sequence Alignments and its Applications
* Genome Modelling
* Gene Sequence analysis
* Primer Designing
* SNP Detection and Haplo typing
* Chromosome Mapping and Linkage Analysis
* Computational Assembly of a Genome


PROTEOMICS

* Protein Sequence Analysis
* Approaches for Protein Structure Predection
* Phylogenetic analysis of Protein Families
* Homology and comparative modeling of protein
* Active site identification


Module:3 DRUG DESIGNING AND DRUG DISCOVERY

( Duration: 1 Month )

DRUG DESIGNING

* Building small molecules
* Properties of Drug molecules
* Ligand protein interactions
* Binding Energy calculations
* Energy minimization methods
* Molecular Dynamics and simulation studies
* Ligand based drug designingFragment based drug designing

DRUG DISCOVERY

* Selection and Identification of Target Concepts in molecular
recognition
* Ligand Docking algorithms
* Kinetics and Thermodynamics of protein drug binding
* Drug delivery

PROJECT WORK IN
Sequence Analysis, Protein Modelling, Structure and Ligand Based Drug
Designing.


SAS FOR LIFE SCIENCES
SAS (Statistical Analysis Systems) is a software used for data
analysis by more than 40,000 customers worldwide. SAS provides many
solutions for life sciences including Optimization of the flow of
Scientific Data, Integration of molecular information with clinical
outcomes, Building a centralized, searchable repository of all
research information, Compliance with regulatory
requirements ,Assessment of safety and effectiveness of new therapies,
Management of Data from various sources like Electronic Data Captures
(EDC), In House Clinical Data Management System (CDMS) and Contract
Research Organizations (CROs),Generation of Presentation-Ready
Statistical Summaries of Clinical Trial and other Biomedical Research
Data.
The Data Analysis and Reporting Tools of SAS are already the Defacto
Standards among Pharma Companies and other Life Science
Industries.USFDA Cosiders SAS Validation as an important Component of
Quality Assurance, Reliability and Accuracy of Information for the
Approval of New Drugs.
This Course will mainly focus on Statistics, Quantitative analysis,
Research Design, and Data management, Data Analysis relating to Life
Sciences.
SAS is used in many fields, particularly in Medical Research and Drug
Development. SAS is best learned as part of a course or through
interactive lessons rather than through self-study. With SAS, we can
dramatically improve our data analysis capabilities and processes, of
ready-to-use statistical analysis procedures and rich, built-in
graphical functionality to reveal relationships and correlations. It
saves time and expenses associated with data manipulation.
This Course also introduces the concept of SAS in life sciences and
also covers Live Projects on Techno-Functional and Functional Modules.
This Course Aims at Creating Man Power in this Hi-Tech , ever growing
and much needed area, who can play a professional role at National and
International level. These Professionals can also enjoy an unique,
Challenging and Profitable Job Profiles.

SCOPE
* Statistical Analysis of Clinical and Research Data using SAS
SoftWare.
* Prepare Custom derived SAS Data Sets.
* Help ion Programming for New Drug Applications(NDAs).
* Preparing repots for Drug Development (Phases I - IV).

COURSE CONTENTS
All Modules: (1-3) : DURATION: THREE MONTHS

* BASE SAS
* SAS MACROS
* SAS/ACCESS
* SAS/CONNECT
* SAS/SQL
* SAS/ETL
* SAS/STAT
* SAS/QC
* SAS/GENETICS


Module 1 Duration: 1 Month

SAS/BASE
* Introduction to SAS Programming
* Importance SAS for Lifesciences
* Creating SAS libraries and Datasets
* Reading Data to Data sets
* Creating permanent libraries in SAS environment
* Reading external source data to SAS Dataset
* Writing SAS Data to external sources
* Importing and Exporting of Data
* Formats and Informats
* Conditional statements
* Automatic variables, Pointers
* Reading Rawdata, Cleaning of Data
* ODS ,DDE ,ARRAYS

BASE SAS PROCEDURES
* Proc Print,Proc Options, Proc Sort , Proc Append
* Proc Transpose ,Proc Forms ,Proc Report , Proc Tabulate
* Proc Import ,Proc Export , Proc Informats , Proc Formats
* Proc Chart , Proc GChart , Proc Plot , Proc Printto etc.


Module 2 Duration: 1 Month


SAS/MACROS
* Introduction to Macros , Statements in Macros
* %Put , %Let , %Mprint ,% Mend , Nested Macros , %Symbolgen
SAS/ CONNECT
SAS/ACCESS
SAS/SQL(PASSTHROUGHFACILITY)
* Oracle
* Creating Datasets by using SAS/SQL
* Updation , Modification , Deletion , Unions , Joins etc.
Module: 3 Duration: 1 Month SAS/STAT
* Introduction to Statistics
* Importance of STAT to Lifesciences
* Proc freq ,Proc rank , Proc corr ,Proc z-test , Proc t-test , Proc
mean
* Proc regg ,Proc anova , Proc GLM etc


SAS/QC
* Introduction to clinical trails
* Cleaning of clinical trail data
* Documentation , SAP introduction , Importance of Biostatistics
* ICH and GCP guidelines , Clinical Data Management System(CDMS)
* Importance of SAS for Regulatory Affairs
* Analysis of Clinical trails results

SAS/ETL
* Connecting to Warehouse Administrator
* Connecting to Oracle Database

SAS/GENETICS

Note: Projects on Functional and Techno-Functional Modules:
(i) Those who are Register for all Three Modules will be given two
live Projects
(ii) Those who have already completed the SAS Course and are
interested only in Projects will be charged Rs: 5000/- per Projects
for the Duration of One Month.

MOLECULAR BIOLOGY
An insight into the Molecules that initiate, control and sustain our
life is called the Science of Molecular Biology. From Mendel's
observation of how Characters were inherited and segregated in the Pea
Plant to the unraveling of the Genome of man and a number of Other
Organisms we have traveled a long way. Molecular Biology and its
related fields like Cloning and Genetic Recombination, have vested
with us the power to combine and exploit the genetic potential of many
organisms for the benefit of mankind. The present Course on these
Molecules is designed to give a hands on experience to the students in
acquainting themselves with the Basic and Advanced techniques in the
field.
Module 1: Basic Techniques: Duration: 20 Days
* Isolation of Genomic DNA from Different Sources
* Isolation of Plasmid DNA
* Competent Cell Preparation
* Genetic Transformation
* Isolation of RNA
* SDS-PAGE
* Characterization of DNA/RNA by agarose Gel Electrophoresis



Module 2: Advanced Techniques: Duration: 20 Days
* Primer designing
* Restriction Digestion
* PCR
* Gene Cloning
* Screening of Cloned Gene
* DNA Fingerprinting
* Genome Analysis
* Southern Blotting
MICRO BIOLOGY
Microbes today have become an intrinsic part of human progress. They
are used industrially in the manufacture of foods, drugs, vaccines,
insecticides, enzymes, hormones and other useful biological products.
These versatile unicellular organisms can be coaxed to produce just
about anything that there is a gene for through Genetic Engineering
and have become the forerunners in the Biotechnology revolution of
modern age. Following courses at different levels are designed to
train students in using the microbes...
Module 1 : BASIC TECHNIQUES IN MICROBIOLOGY Duration: 20 Days
* Sterilization Techniques
* Preparation of Media
* Isolation of Microorganisms from different Sources
* Identification and Characterization of some important microbes
* Preservartion and Maintenance of Microbial cultures
* Studies on the Growth Kinetics of Bacteria
* Studies on Microbial Antibiosis
* One Step Growth of Bacteriphages
Module 2 : ADVANCED TECHNIQUES IN MICROBIOLOGY
Duration: 20 Days
* Isolation of industrially important bacteria
* Development of new strains by Mutations
* Analysis of Extracellular Enzymes from Bacteria
* Isolation of Genomic DNA from Bacteria
* Restriction Digestion
* Transformation and Selection of Tranformants
* Conjugation in Bacteria
* Chromatography Techniques
Module 3: INDUSTRIAL MICROBIOLOGY INCLUDING R&D AND QUALITY CONTROL
Duration: 20 Days
* Isolation, Identification and Maintenance of Industrially important
Microorganisms
* Testing of Industrial products for Microbial Quality
* Testing Chemicals for Carcinigenecity
* Testing Water samples used for Food , Drug and Mineral Water
Producing Industries.
* Enzyme Immobilization
IMMUNOLOGY
Module 1 : BASIC TECHNIQUES IN IMMUNOLOGY Duration: 20 Days
* Serological identification of unknown pathogen
* Determination of antibody titre
* Latex agglutination text
* Rapid immunology diagnostic procedures for STDs
* Radial immuno diffusion test
Module 2 : ADVANCED TECHNIQUES IN IMMUNOLOGY Duration: 20 Days
* Febrile antibody test
* Immunodiffusion
* Counter current immunoelectrophoresis
* Rocket immunoelectrophoresis
* ELISA
* Western blotting
TISSUE CULTURE
PLANT TISSUE CULTURE
* Preparation of MS Medium
* Callus induction from different explants
* Shoot Induction
* Root Induction
* Micro propagation/Multiple shoot induction
* Genetic Transformation using Agro bacterium
* Hairy root culture
* immobilization of Cells

Address
Prof: N.V .Naidu. M.S., Ph.D.
Director of Studies,
Global Institute of Biotechnology,
3-6-276/2, Above Mahesh Bank,
Himayat Nagar,
Hyderabad-29.
[Only registered users see links. ]
[Only registered users see links. ]
Contact No:
Ph: 040-66621528
093910 05048



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