formaldehyde induced arthritis

Dear all,
I am working on chronic inflammation, in which i'll be inducing
arthritis by injecting 2% formaldehyde into the plantar region of the
rat's hind paw, and i'll be testing the activity of a plant extract
for its anti-arthritic effect.
In literature it has been recorded that the treatment period is for 10
days(on day 1 arthritis will be induced and an another injection of
formaldehyde will be given on day 3 and the treatment will be given
orally starting from day 1 until day 10), is it an enough period for
arthritis to occur and be treated? and what is the mechanism that
formaldehyde will induce arthritis? and why should i inject the rat
twice with formaldehyde?
Thank you
Yara Malakha
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