I am still in awe that the complexity of the human body can be reached with just ~25,000 genes. Makes me imagine that it will someday be possible to design a totally new organism. Here are some interesting figures to ponder: Human figures: Genome size:
~25,000 Proteome size:
Estimates range from 23,000 to 120,000, with an average estimate of 50,000 (Harrison et al. 2002) Figures of the entire protein universe: Number of different protein folds:
Estimates range from ~1,000 to ~10,000 (Grant et al. 2004). SCOP currently contains ~1,000 Number of different protein-protein interaction types:
~10,000 (of which 2000 are currently known) (Aloy et al. 2004)
It would be interesting to know how many biological functions there are in human. Does anyone know?
And do you know how many different folds are present in the human proteome? C. elegans has 600 (Qiana et al. 2001) References:
Paul M. Harrison, Anuj Kumar, Ning Lang, Michael Snyder and Mark Gerstein A question of size: the eukaryotic proteome and the problems in defining it
Nucleic Acids Research, 2002, Vol. 30, No. 5 1083-1090
Alastair Grant, David Lee, and Christine Orengo. Progress towards mapping the universe of protein folds Genome Biol. 2004; 5(5): 107.
P. Aloy and R.B. Russell, Ten thousand interactions for the molecular biologist, Nat Biotechnol 22 (2004), pp. 1317–1321.
Jiang Qiana, Nicholas M. Luscombea, and Mark Gerstein Protein family and fold occurrence in genomes: power-law behaviour and evolutionary model Journal of Molecular Biology Volume 313, Issue 4 , 2 November 2001, Pages 673-681