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Possible strategies to block a membrane pore (individual monomer of a protein)?

Possible strategies to block a membrane pore (individual monomer of a protein)? - Protein Science

Possible strategies to block a membrane pore (individual monomer of a protein)? - Post Questions and Discuss Protein Structure and Function, Protein Localization etc.. Please do not post Proteomic questions here, there is a Proteomic Forum below.


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Old 10-06-2007, 10:39 PM
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Unhappy Possible strategies to block a membrane pore (individual monomer of a protein)?



Hi everybody,
What could be the means to completely block the pore of individual monomers in a membrane protein against solute molecules? The protein expression MUST NOT be hindered at all. The only change should be blockage of the monomer’s pore. I am particularly interested in a strategy other than substitution mutations. Thanks in advance for your information.
Saad

Last edited by Saad; 10-09-2007 at 07:36 PM. Reason: The previous question didnt fully reflect my objectives.
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Old 10-08-2007, 02:43 PM
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Default Re: Possible strategies to block a membrane pore (individual monomer of a protein)?

Competitive inhibition with an inert analog to the active site, intrabody (intracellular antibody), silencer RNA (RNAi).
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