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Possible strategies to block a membrane pore (individual monomer of a protein)?
What could be the means to completely block the pore of individual monomers in a membrane protein against solute molecules? The protein expression MUST NOT be hindered at all. The only change should be blockage of the monomer’s pore. I am particularly interested in a strategy other than substitution mutations. Thanks in advance for your information.
Last edited by Saad; 10-09-2007 at 07:36 PM. Reason: The previous question didnt fully reflect my objectives.
Re: Possible strategies to block a membrane pore (individual monomer of a protein)?
Competitive inhibition with an inert analog to the active site, intrabody (intracellular antibody), silencer RNA (RNAi).
|block , individual , membrane , monomer , pore , protein , strategies|
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