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-   -   Question about net charge of peptides at pH=1? (http://www.molecularstation.com/forum/peptide-forum/87560-question-about-net-charge-peptides-ph%3D1.html)

?°•GURU•°? 02-13-2013 04:15 PM

Question about net charge of peptides at pH=1?
 
Can you just assume that each amino acid at pH 1 would have a +1 charge? As in if there are 15 amino acids in a peptide, no matter what they are, the charge would be +15, since each amino acid would be charged?

Can this be true about pH=14, where all the amino acids would be deprotonated so the net charge would be -15?

Kunal Pandya 04-03-2013 09:12 AM

Re: Question about net charge of peptides at pH=1?
 
It not possible in either way as you are not specified amino acid. you are true that each amino acid at pH 1 would have a +1 charge (Avoid side chain) but same is not true for peptide as in peptide amino acid are linked through peptide bond so at that time not Amino and nor carboxyl part of aminoacid { amide bond having zero charge) will contribute any charge (Only N terminal amino acid contribute +1 at pH 1 and Carboxyl terminal amino acid contribute -1 at pH 14, again I am, not including charges which are due to side chain functionality)

GlennHardin 09-09-2014 12:02 AM

Re: Question about net charge of peptides at pH=1?
 
It's a very complex subject and something that most of us cannot get our heads around. As far as I know at PH1 each and every one amino acid would have a +1 charge associated with it.


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