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-   -   Does pepsin break protein into peptides or polypeptides? (http://www.molecularstation.com/forum/peptide-forum/86807-does-pepsin-break-protein-into-peptides-polypeptides.html)

Jessica 11-13-2012 11:17 PM

Does pepsin break protein into peptides or polypeptides?
 
I need to know this for a bio test and am not sure which it is. Thanks!

niko 11-13-2012 11:17 PM

Pepsin is an enzyme whose zymogen (pepsinogen) is released by the chief cells in the stomach and that degrades food proteins into peptides.

Kunal Pandya 11-16-2012 04:45 AM

Re: Does pepsin break protein into peptides or polypeptides?
 
Pepsin is relatively non-specific although it does have a preference for cleaving after hydrophobic amino acids in protein,peptide, polypeptide . Pepsin breack peptide bond between hydrophobic peptide like phenylalanine, tryptophan, Tyrosine.

Pepsin will also preferentially cleave at the carboxyl side of phenylalanine and leucine and to a lesser extent at the carboxyl side of glutamic acid residues.Amidation of the C-terminal carboxyl group prevents hydrolysis by pepsin.

or e.g. :- Pepsin Cleaves Phe1-Val, Gln4-His, Glu13-Ala, Ala14-Leu, Leu15-Tyr, Tyr16-Leu, Gly23-Phe, Phe24-Phe and Phe25-Tyr bonds in the B chain of insulin.


Regards


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