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-   -   Finding net charge on a peptide? (http://www.molecularstation.com/forum/peptide-forum/86596-finding-net-charge-peptide.html)

Hermione Granger 10-07-2012 01:19 AM

Finding net charge on a peptide?
 
Consider the net charge on the peptide AAAADEHKRAAA dissolved in an aqueous solution. Suppose the pH is raised from 2 to 8.5. Ignoring the charges that may exist on the N- and C-termini, what is the correct charge on the peptide?

a. from +2 to +5
b. from +3 to +5
c. from +3 to 0.
d. from 0 to +2

Thanks so much!

Kunal Pandya 10-08-2012 03:44 AM

Re: Finding net charge on a peptide?
 
C) +3 to 0

At pH 2 Side chain Asp (D) and Glu (E) having 0Charge while His(H), Lys(K),Arg (R) having +1 Charge each so total +2 charge .

Net charge at pH 2 is +3 (Ignoring N and C termini amino acid)

At pH 8.5 Side chain Asp (D) and Glu (E) having -1 Charge each so total -2 Charge while His(H) having 0 charge , while Lys(K),Arg (R) having +1 Charge each so total +2 charge

Net charge at pH 8.5 is 0 (+2 - 2) (Ignoring N and C termini amino acid)


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