AICAr rats, dosage up to 250mg/kg ?

[Gepetto]

Hello,
I just read this interesting study on pubmed. What strikes me as odd is the enormous does of AICA ribonucleotide that those rats were given and more specifically 250mg/kg.

An overly fed fat rat should weight about one kilo. Which means 250mg/day
Now I opened the first peptides site I found in Google and apparently 100mg of AICAr cost about $65. Now if you were to treat a dog say a rottweiler, an adult one usually weighs about 60kg. That equals 15g/day which would cost almost $10000/day to maintain.

At the same time I've read in underground bodybuilding forums that athletes would use this substance at no more than 10-15mg/day. Apparently those engaged in endurance sports can benefit the most out of AICAr.

Do you have any idea what's with the enormous difference in doses ? Is it possible that athletes are only getting a placebo effect out of this small dose ? Thanks.