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Peptide as a drug

Peptide as a drug - Peptide Forum

Peptide as a drug - Peptide Forum. Ask and discuss questions on peptide protocols, custom peptide synthesis, peptide identification and peptide sequencing.


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Old 06-11-2012, 05:43 AM
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Smile Peptide as a drug



peptide drugs provides a safe treatment option because peptides are organic to the body itself.No other class of biological molecule offer the range of chemical diversity that peptide anmd protein possess.In so far as they are composed of naturally occurring amino acids ,they are generally non-toxic. peptide have not always been popular candidate for drugs due to their chemical structure ,were expensive and complicated pharmeceuticals to synthesize, but now a days it not true and many pharmaceutical companies and reserch group show more interest in peptide drugas as chance of succes is more in it.

Peptide drugs have a long and secure future

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Old 07-11-2012, 03:58 AM
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Arrow Re: Peptide as a drug

peptides still need to surmount hurdles such as their high R&D expenses and difficult scalability. Yet they are drawing attention such that the global market for peptide-based active pharmaceutical ingredients (APIs) is expected to expand at a "growth rate nearly double the growth rate for APIs overall,"

The U.S. holds 65% of the worldwide therapeutic peptides market. Europe is 30% of the total, with Germany and the U.K. in the lead. Japan dominates activity in Asia.

There are more than 40 marketed peptides worldwide, around 270 peptides in clinical phase testing, and about 400 in advanced preclinical phases. Natural peptides such as insulin, vancomycin, oxytocin, and cyclosporine and synthetically produced ones such as Fuzeon (enfuvirtide) and Integrilin (eptifibatide) and many more are among the approved peptide-based drugs
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Old 07-16-2012, 04:57 AM
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Smile Antimicrobial peptides

Antimicrobial peptides are being increasingly recognised as potential candidate antibacterial drugs in the face of the rapidly emerging bacterial resistance to conventional antibiotics in recent years. However, a precise understanding of the relationship between antimicrobial peptide structure and their cytolytic function in a range of organisms is still lacking. This is a result of the complex nature of the interactions of antimicrobial peptides with the cell membrane, the mechanism of which can vary considerably between different classes of antimicrobial peptides. Antimicrobial peptide action is mediated by a direct interaction with cell membranes and a common feature of these interactions is the induction of cationic amphipathic secondary structure following binding of the peptides to the membrane surface. Since selective binding to different phospholipids is central to the design of non-hemolytic antimicrobial peptides, the affinity of the peptide for the membrane surface is a critical factor in the cell-lytic process. We have developed a sensitive method based on surface plasmon resonance (SPR), which allows the real-time measurement of peptide binding to phospholipid membranes. The project area focuses on characterising the molecular basis of antimicrobial peptide action to assist the direct design of more potent and selective antimicrobial peptides as leads from new therapeutics for the treatment of bacterial infections.
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Old 07-19-2012, 05:50 AM
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Thumbs up Re: Peptide as a drug

Peptide drug conjugates and cancer treatment

Peptide-drug conjugates (PDCs) are structurally simple and include a peptide that selectively targets cancer cells, a potent cell killing drug molecule, and linker chemistry which can be tuned so the conjugate exhibits the desired pharmacologic properties. PDCs share the promise of antibody-drug conjugates (ADCs), but can be faster and simpler to develop. As evidenced by clinical data from other developers, guided therapeutics such as ADCs and PDCs are a promising new frontier in cancer treatment because they hunt and destroy primary and metastatic cancer cells with greater safety margin.

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