How does ERAP-1 know to trim peptides longer than 8-9 amino acids in antigen

qwrqw q · #1 (**permalink**) 11-07-2009, 08:19 PM

processing? I know endoplasmic reticulum aminopeptidase 1 trims the peptides but I can't find anywhere HOW this is regulated? How does it 'know' they are the wrong size? There must be a mechanism.

hcbiochem · #2 (**permalink**) 11-07-2009, 08:19 PM

Perhaps it just randomly trims peptides, and those that are the right size bind to the MHC protein.

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How does ERAP-1 know to trim peptides longer than 8-9 amino acids in antigen

How does ERAP-1 know to trim peptides longer than 8-9 amino acids in antigen - Peptide Forum

How does ERAP-1 know to trim peptides longer than 8-9 amino acids in antigen - Peptide Forum. Ask and discuss questions on peptide protocols, custom peptide synthesis, peptide identification and peptide sequencing.