What are the different techniques are there in peptide synthesis such N-

[Kaushil]

Methylation, N- capping, acetlyation? i know that in peptide synthesis there are mainly two method of synthesis
1) solid phase peptide synthesis
2) solution phase peptide synthesis

but during synthesis the unnatural amino acid are synthesis and also they are protected to avoid degaration etc

so what are those possiblities of modification in peptide synthesis

i know some of them
1) N- Capping
2) N- Methylation
3)Acetlyation etc

can any one tell me how we can introduce Sulfur and phosphor group , sulfide linkage

what those techniques are known as or any other techniques if u know?

and good online resource if you know

[holmerz]

Hi
I'm not quite sure what you are asking for! I think N-acetylation is the most common N-terminal modification.


Disulfide bridges between two peptide can be introduced by using Fmoc-Cys(StBu)-OH. The StBu protecting group is stable to acid and base and is removed by oxidation following the cleavage and purification of the StBu protected peptide.

Chemistry - A European Journal
Volume 9 Issue 15, Pages 3703 - 3714

.chempep.com/ChemPep-Fmoc-Solid-Phase-Peptide-Synthesis.htm#C41

\Erik