Hctu

[a_m_shaheen]

Hello:
i wonder if anybody tried to use HCTU in his synthesis and found how good it is over HBTU. another question i am using right now HBTU and HOBt for my synthesis and i noticed that it turned brownish as the peptide synthesis go if there is any solution for that.

thanks in advance

[glbiochem]

We manufacture both HCTU and HBTU. But few people inquire the HCTU.
The automachine engineer suggested us use HCTU to get a high coupling efficiency in synthesis.

As most of our peptides were synthesized by manual, we can coupling twice or 3 times to block most of free amine, so we did not follow his suggestion and do not have such comparing data.

If you have interest to try, you may purchase some HCTU from us to make such test. I can provide a special price for it.

[adrianandreica]

We are using only HCTU for both automated and manual synthesis. It is more efficient and is a lower allergen (we had collegues that they had pretty bad allergic reactions to HBTU).

[glbiochem]

Maybe you are right. If you had some data to show, it would be better.
The FOB price of HBTU is only US$70/Kg, HCTU reached US$440/Kg.
The big difference on the price is caused by the manufacture scale. We manufacture several ton HBTU, but the HCTU only tens of Kgs.

I hope your research work can attract more people to use this product.
With our manufacture scale-up, we would cut down much price on HCTU.

[a_m_shaheen]

Originally Posted by glbiochem

Maybe you are right. If you had some data to show, it would be better.
The FOB price of HBTU is only US$70/Kg, HCTU reached US$440/Kg.
The big difference on the price is caused by the manufacture scale. We manufacture several ton HBTU, but the HCTU only tens of Kgs.

I hope your research work can attract more people to use this product.
With our manufacture scale-up, we would cut down much price on HCTU.

thanks glbiochem for your reply, can you please give me the details of your company.

[glbiochem]

Please see it in below two weblinks to know more about us
http://www.echinachem.com/glschina.co/en
http://www.glbiochem.com/en/profile.htm

BTW, you can send email to my work mail for the spec. & COA & catalogue.
davidwei@glbiochem.com

[ask03]

Originally Posted by a_m_shaheen

Hello:
i wonder if anybody tried to use HCTU in his synthesis and found how good it is over HBTU. another question i am using right now HBTU and HOBt for my synthesis and i noticed that it turned brownish as the peptide synthesis go if there is any solution for that.

thanks in advance

This paper is I think best for the kind of comparison you are looking for shaheen. hope it helps...

Journal of Peptide Science
J. Pept. Sci. 2008; 14: 97–101
Published online 24 September 2007 in Wiley InterScience (www.interscience.wiley.com). DOI: 10.1002/psc.921
Fast conventional Fmoc solid-phase peptide synthesis with
HCTU