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Covalent modifications to improve solubility of sparingly soluble substrates

Covalent modifications to improve solubility of sparingly soluble substrates - Organic Chemistry Forum

Covalent modifications to improve solubility of sparingly soluble substrates - Organic Chemistry Forum


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Old 02-06-2004, 09:50 PM
sweetysom
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Default Covalent modifications to improve solubility of sparingly soluble substrates




I am looking for some covalent modifications that can be done to
either diphenylacetylene(DPA) or biphenyl (target substrates in our
research) to increase their aqueous solubility in E.coli growth
system.. So far, I have modified biphenyl to sulfonatedbiphenyl
(obtained commercially as biphenylsulfonic acid). However, due to
larger polarity of sulfonic group, the molecule as a whole is unable
to enter the inner part of the cell. Currently, I am working with
surfactants to enhance the solubility of DPA and also aid in their
transport.

Could you suggest some me some substrate covalent modifications to
biphenyl. Thankyou for your time.
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Paul J. Franklin(moderator - sci.chem.organic.synthesis)
[Only registered users see links. ]
Georgia State University <[Only registered users see links. ].edu>
Atlanta, GA
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