Im doing a genomics assignment on exon shuffling where i must characterise the cellular function of a protein. (using all the usual computational and database software)
Ive got a frizzled (though missing a few disulphide bridges) domain in my protein. I think i understand that this family of proteins are transmembrane proteins which act as receptors for signalling proteins... but then again i dont really understand what these frizzled domains do!! A read of all significant matches conducted in BLASTp turns up many and varied explanations for what these frizzled things are involved in.(developing hair follicles, schizophrenia... the list goes on!)
I cant seem to find any simple answers looking through scholarly papers either.
If i had a notion of what these frizzled domains do then i may have less trouble looking for papers that actually relate to the protein at hand.
Thanks in advance for any information or arrows in the right direction