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About FGFR inhibitors

About FGFR inhibitors - Molecular Biology Products and Vendors

About FGFR inhibitors - Discuss Molecular Biology Products, Vendors and Equipment.


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Old 02-17-2012, 05:59 AM
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Default About FGFR inhibitors



FGFR inhibitors

BIBF1120 (Vargatef)

BIBF1120 (Vargatef) is an inhibitor of VEGFR, PDGFR and FGFR. all three VEGFR subtypes (IC50=13–34nmol/L) , PDGFRa and PDGFRh (IC50=59and65nmol/L) , and FGFRtypes 1, 2, and 3 (IC50=69, 37, and 108 nmol/L,respectively).

Danusertib (PHA-739358)

Danusertib (PHA-739358) is a pyrrolo-pyrazole and small molecule Aurora kinases and Bcr-Abl kinase inhibitor with IC50 of 13, 79, and 61 nM for Aurora A, B, and C, respectively.

Dovitinib (TKI258)

Dovitinib (TKI258) is a highly potent, novel multitargeted growth factor receptor kinase inhibitor with IC50 of 1, 2, 5, 10, 8, 27, 36 nM for FLT3, c-KIT, FGFR, VEGFR1/2/3, PDGFR? and CSF-1R, respectively.
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