Let's Talk About The Prion Proteins (PrP) Technology and Potential!!!!!!

[see_harke]

Hiiii all. I'm a newbie at this forum. I'm currently a student of biology departement. I'm interested in the potential of the prion protein. If there's anybody has any news or articles 'bout the PrP, let's post it here and discuss it....

Good luck for U all!!!

[moleculardude]

Hello See!

very interesting topic PrP is! I have studied it in my graduate courses. Tell me what you are interested in!

[see_harke]

Oh My God!!!!!!!

this is the first time I can reply the message since a month ago!! I lost my password but it's ok now....

Hi, Mr. Moleculardude!! Sorry replying you so long!!!!

Wow,,where did U study ur graduate and Ph.D program?? that must be so interesting to get a course to study about Prp!! U know, I wish for it, although my english still not yet very well

This is my idea. I've made it in an article that I've sent for a scholarships in easyaid.com, but I guess I wouldn't get the aid...

Or you can see it at my blog: harkpratama.blogspot.com


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Prion: The Future Molecules

Mad Cow Disease, and Creutzfeld-Jakob Disease for human version, is quite familiar in our ears since years ago. At the early of the disease found, almost all of the researchers concluded that it caused by some kind of virus, except Mr. Stanley Prusiner who received the Nobel Prize for his invention of the prion protein which caused the disease. After that, many scientists try to research the prion deeper.
What happens now, according to one of the scientific magazine in US, are just a few students who has an interest in the prion research. I don’t know exactly what the reason they have, but maybe they think that the prion research will give no more future chances than other field of research. I can’t imagine how Mr. Prusiner will sadly says “No” if he hears about it.
One of the shocking researches I know about the prion has ran by Dr. Lindquist and her team at Boston since years ago. They found that the normal prion injected to the mice brain help the brain to make a new brain neuron, even if it injected in adult mice. Although they haven’t yet found –and the research still running- how that normal prion work to help it happen, they obtain that the prion protein do it.
I just feel it something different with what almost people think about that kind of protein: it surely just a disease. Exactly not, if the prion in the normal structure. What happens to the mad cow disease is the proteins have an abnormal structure. So, now, is there anybody think wildly about the future chances of that macromolecules, after I tell that the scientist have already found that the prion protein exists on many different cell types throughout the body, not only at the brain?
In my mind, the prion seems will be one of the next future hope in medical to so much people who lost their body part, like hand or leg, caused of amputation or an accident, or to fix another problem that need new cells and new tissues. Just think about the prion work and help building the new cells, then synthesis the new tissues, and finally the new leg or hand appears almost naturally! Although seems not so easy like that.
The process could take a long time, and sure, that will be not funny things when we have a baby’s size leg while our faces are seen already have three grandchildren. But, according to the gene expression control, we can run the process and stop it running by repressing the way it work with the drugs help. The field of molecular biology and biochemistry today can make it real, even less tomorrow.
And the applications don’t stop there. Wanna have a Tom Cruise or J-Lo face? You’ll get it with a plastic surgery. Isn’t horrified? Yes, I know it. But, if the prion can be applicated to build a new skin cells naturally, it can be used to do it with a slow motion unfelt process, and it can be also applicated for burned or injured skin. It’s just one of the samples.
That’s so many things we can do with the prion protein. The ability of that protein gives us so many questions to be answered, so much secret to be explored. And God will never give even one tiny molecule naturally in our body without any function. Just let’s explore it, then thanks God for the gifts.

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[admin]

Awesome stuff there See_harke!
I think PrPs have many utilities that we can soon discover! Their properties are very unique.

[see_harke]

Oow...thanks a lot Mr. Admin!!


This is my sorting result from sites that I guess can be related with the PrP. I've got the idea from that too

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In collaborative work with the labs of Jeffrey Macklis and Harvey Lodish, we have been investigating the normal function of mammalian PrP. PrP is normally expressed on the surface of bone marrow stem cells and neuronal precursors. In both systems lack of normal PrP expression, as seen in PrP knockout mice, seems to result in fewer mature cells.
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Our recent experiments suggest that the presence of PrP in the cytosol rather than in its normal cell surface location may be the cause of neurodegeneration in prion diseases.
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"The more PrP you have, the faster you become a neuron. The less you have, the longer you'll stay in a precursor state," says graduate student Andrew Steele.

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or another article at mit.edu

Is there anybody wish to 'realizating' this idea?
I wish...