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B-lymphocytes in autoimmune thryroid diseases (AITD)

B-lymphocytes in autoimmune thryroid diseases (AITD) - Molecular Biology Articles and Protocols

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Old 07-01-2010, 02:09 PM
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Default B-lymphocytes in autoimmune thryroid diseases (AITD)



1. I found a note in a book about immune system that antibody can be produced not only by plasma cells, but also by "normal" B-cell. Is this true?
2. I also found an article: "B-lymphocytes in autoimmune thryroid diseases (AITD)" by Robert Volpe http: //www .springerlink .com /content /jmq11w4g0466k452/ (put all together) and there is info about the difference of autoagressive antibodies production by lymphocytes B of thyroid in comparison to those B-cells from peripheral blood and lymph nodes. I just don't understand how they distinguished antobodies produced by cells from blood and thyroid if lymphocyte B needs to get to lymph node in order to change into plasmoblasts and then to get matured in bone marrow or spleen into plasmocytes. Does it mean that those B-cells produce antobodies in thyroid? I am so confused and i feel like all my knowledge went to nowhere.
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