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DNA Footprinting

DNA Footprinting - Molecular Biology Articles and Protocols

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Old 08-12-2009, 10:45 PM
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Default DNA Footprinting



Broadly, the position of non-sequence-specific proteins, such as nucleosomal proteins, along a specimen of DNA is best footprinted with micrococcal nuclease rather than DNAse1.

On the other hand, the twist of DNA around a nucleosome, or the position along a specimen of DNA of sequence-specific proteins, is best footprinted with DNAse1 rather than micrococcal nuclease.

If the reason for this difference interests you, I believe I have identified the answer in scientificjournals.org/.../1098_DNA%20Footprinting--Hitherto%20Unaddressed%20Problems.pdf
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